HAND2
-
Official Full Name
heart and neural crest derivatives expressed 2 -
Overview
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. -
Synonyms
HAND2;heart and neural crest derivatives expressed 2;heart- and neural crest derivatives-expressed protein 2;bHLHa26;dHand;Hed;Thing2;class A basic helix-loop-helix protein 26;basic helix-loop-helix transcription factor HAND2;deciduum, heart, aut
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&Fc&Avi
Involved Pathway
HAND2 involved in several pathways and played different roles in them. We selected most pathways HAND2 participated on our site, such as Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity,Neuronal System,Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAND2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | SLC1A3A,NSFB,KCNK13B,KCNA5,KCNG4A,SLC6A1A,RAB3AA,PANX1,KCNC1A,CHRNA1 |
| Trafficking of AMPA receptors | GRIP1,PICK1 |
| Transmission across Chemical Synapses | SNAP25B,LIN7C,SLC1A2B,CPLX2L,SLC1A7A,SYN2,CACNG2B,SYT1A,SYN1,Apba1 |
| Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | CACNG2,NSFA,NSFB,MYO6,AKAP5,GRIP1,CACNG3,PICK1 |
| Trafficking of GluR2-containing AMPA receptors | PICK1,GRIP1 |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | PICK1,MYO6,GABRR2A,CHRNA2,NSFA,CHRNA5,CHRND,CAMKK1B,NCALDA,DLG1L |
Protein Function
HAND2 has several biochemical functions, for example, ATPase activity,Arp2/3 complex binding,G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAND2 itself. We selected most functions HAND2 had, and list some proteins which have the same functions with HAND2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | RHOA,IPCEF1,WHRN,ATN1,MPP5,SLC34A2,HIST1H4D,IST1,ICA1,HGS |
| actin filament binding | ADSSL1,TRPV4,PPP1R9A,CAPZB,VIL1,MYH9,CTNNA2,AIF1,ACTN2B,MYO3A |
| protein C-terminus binding | SNF8,MLLT4,HOMER3,PICK1,DAB2,OPRL1,XRCC6,CD2AP,DBNL,PPM1A |
| Arp2/3 complex binding | WHAMM,GMFB,SNX9,CORO1B,GMFG,ARPC2,PICK1 |
| metal ion binding | LMO7B,STAC,RTEL1,PFAS,FHL2A,CXXC1A,CYP2C55,DTD1,RACGAP1,ZNF566 |
| identical protein binding | ATXN3,GOT2A,GNPNAT1,RGMB,ATG16L1,ROBO2,DVL2,SDF4,SH3GL3,TRIM23 |
| G-protein coupled receptor binding | GNA11A,QRFP,GNAI2B,POMC,PSAP,GNA14,PICK1,PARK2,ITGB4,NMS |
| ATPase activity | ACTC1,ABCG2C,MYH8,SWSAP1,ABCF3,ATAD2B,KIF1B,KIF3C,IDE,TOR1B |
| receptor binding | PVRL3,HRG,PTK6B,LYN,GNB2L1,PPY,PVRL2,NRTN,EPB49,YES1 |
Interacting Protein
HAND2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAND2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HAND2.
TCF4
Resources
Related Services
Related Products
References
