HACE1
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Official Full Name
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -
Synonyms
HACE1;HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1;E3 ubiquitin-protein ligase HACE1;KIAA1320;HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1;HECT domain and ankyrin repeat containing, E3 ubiquitin p
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- Mammalian cells
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
HACE1 involved in several pathways and played different roles in them. We selected most pathways HACE1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HACE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HACE1 has several biochemical functions, for example, Rab GTPase binding,Rac GTPase binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HACE1 itself. We selected most functions HACE1 had, and list some proteins which have the same functions with HACE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rac GTPase binding | ARHGAP4A,MAP3K11,NOXA1,SRGAP1,DOCK7,ARHGEF2,RAB7,CAV1,NOX1,CDKL5 |
| Rab GTPase binding | RPH3A,TBC1D7,MICAL1,PPIAL4A,RAB11FIP4B,USP6NL,ANXA2,RAB11FIP5,RUSC2,RABGGTB |
| ligase activity | RNF144B,RNF185,PJA1,SH3RF2,RNF43,NEURL1B,ARIH1,CCNB1IP1,BARD1,PIAS4 |
| protein binding | GH1,PPP3R1,COMMD8,BMP1,CBX1,FAP,STARD3,MICALL1,MT1H,ACY3 |
| ubiquitin protein ligase activity | UBE2N,UBE2C,MARCH8,RNF146,CBLC,TRIM24,BTRC,RNF34,SMURF1,RAG1 |
| ubiquitin-protein transferase activity | ZYG11,ZNRF1,XIAP,LTN1,MDM2,DTX3L,PDZRN3B,ARIH1,UBE2G2,SMURF1 |
Interacting Protein
HACE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HACE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HACE1.
OPTN;ubiq_human;USP2;UBA1
Resources
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References
- Rotblat, B; Southwell, AL; et al. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:3032-3037(2014).
- Castillo-Lluva, S; Tan, CT; et al. The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation. ONCOGENE 32:1735-1742(2013).
