H2AFY2
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Official Full Name
H2A histone family, member Y2 -
Overview
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation. -
Synonyms
H2AFY2;H2A histone family, member Y2;macroH2A2;core histone macro-H2A.2;mH2A2;histone macroH2A2;core histone macroH2A2.2
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| H2AFY2-13648H | Recombinant Full Length Human H2AFY2 | E.coli | Human | His | Full L. 1-372 a.a. | |
| H2AFY2-2029R | Recombinant Rhesus monkey H2AFY2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| H2AFY2-30081TH | Recombinant Human H2AFY2, His-tagged | E.coli | Human | His | 164-372 a.a. |
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| H2AFY2-3124Z | Recombinant Zebrafish H2AFY2 | Mammalian Cell | Zebrafish | His |
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| H2AFY2-4539H | Recombinant Human H2AFY2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| H2AFY2-4762C | Recombinant Chicken H2AFY2 | Mammalian Cell | Chicken | His |
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| H2AFY2-7431M | Recombinant Mouse H2AFY2 Protein | Mammalian Cell | Mouse | His |
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| H2AFY2-5656HCL | Recombinant Human H2AFY2 293 Cell Lysate | HEK293 | Human | Non |
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| H2AFY2-1850R | Recombinant Rhesus Macaque H2AFY2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| H2AFY2-1850R-B | Recombinant Rhesus Macaque H2AFY2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| H2AFY2-3405HF | Recombinant Full Length Human H2AFY2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 372 amino acids |
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| H2AFY2-4043M | Recombinant Mouse H2AFY2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| H2AFY2-4043M-B | Recombinant Mouse H2AFY2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
H2AFY2 involved in several pathways and played different roles in them. We selected most pathways H2AFY2 participated on our site, such as Alcoholism,Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H2AFY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | GNB3,HIST1H2BP,HDAC5,CALML5,HIST1H3C,HDAC2,HIST1H2AG,CALM4,BDNF,GNGT2 |
| Systemic lupus erythematosus | HIST1H2BL,HIST1H3E,HIST2H2AA4,H2AFB2,Hc,HIST1H3H,H2AFX,TNF,CD86,HIST1H4M |
Protein Function
H2AFY2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin DNA binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by H2AFY2 itself. We selected most functions H2AFY2 had, and list some proteins which have the same functions with H2AFY2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin DNA binding | RXRA,AASS,MED1,NKAP,HIST1H1B,GRHL3,ACTN4,WBP2,RARA,PPARGC1A |
| transcription regulatory region DNA binding | WT1,TP63,MZF1,FOXA2,SOX6,TAF9,KLF2A,RREB1,SOX7,KLF1 |
| protein heterodimerization activity | TXLNG,NFYBB,ADRA2C,UGT1A6B,HAND1,HER5,HIST1H2A9,SMC2,HIST1H4J,HIST1H2BN |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF256,ZFY2,FOXF1,AIRE,GATA1A,KAT2B,ZFP39,TRP53,CEBPB,LEF1 |
Interacting Protein
H2AFY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H2AFY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of H2AFY2.
CDC37;WWP1;PYHIN1
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References
- Tanasijevic, B; Rasmussen, TP; et al. X Chromosome Inactivation and Differentiation Occur Readily in ES Cells Doubly-Deficient for MacroH2A1 and MacroH2A2. PLOS ONE 6:-(2011).
- Geigl, JB; Langer, S; et al. Analysis of gene expression patterns and chromosomal changes associated with aging. CANCER RESEARCH 64:8550-8557(2004).
