Gpt2
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Official Full Name
glutamic pyruvate transaminase (alanine aminotransferase) 2 -
Overview
GPT (MIM 138200) and GPT2 (EC 2.6.1.2), also known as alanine transaminases, are pyridoxal enzymes that catalyze the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. By mediating the conversion of these 4 major intermediate metabolites, these transaminases have roles in gluconeogenesis and in amino acid metabolism. -
Synonyms
GPT2;glutamic pyruvate transaminase (alanine aminotransferase) 2;alanine aminotransferase 2;ALT2;AAT2;Glutamate pyruvate transaminase 2;Glutamic alanine transaminase 2;Glutamic pyruvic transaminase 2;GPT 2;glutamic--alanine transaminase 2;glutamic--pyruvic transaminase 2;glutamic-pyruvate transaminase 2
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Arabidopsis thaliana
- S.cerevisiae
- E.coli
- Insect Cells
- Mammalian Cell
- Insect Cell
- Rabbit
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- Flag
- N-His&C-Myc
- Myc&DDK
Involved Pathway
Gpt2 involved in several pathways and played different roles in them. We selected most pathways Gpt2 participated on our site, such as Arginine biosynthesis,Alanine, aspartate and glutamate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gpt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbon metabolism | PKMB,ALDOCA,PGK2,MUT,ENO1B,TKTL1,GOT1,MDH1AA,TKT,FBP2 |
| Arginine biosynthesis | GLUD1,OTC,GLUD2,ybaS,GLUL,ARG2,NOS1,GOT2B,ASL,GPT2L |
| Biosynthesis of amino acids | IDH2,PC,PGAM1A,ALDOA,SHMT2,PYCR2,MAT2AL,IDH3B,MAT2AA,ASL2 |
| -Oxocarboxylic acid metabolism | GOT2B,BCAT1,GPT,ACO1,GPT2L,AADAT,BCAT2,GOT1,GOT2A,ACY1 |
| Alanine, aspartate and glutamate metabolism | AGXTA,AGXTB,ASL2,ASS1,ALDH5A1,GLSA,ADSS,ASPA,CPS1,GOT2 |
| Metabolic pathways | ACOT2,PDXKB,PPAP2C,AOX1,DLDH,AOC2,SLC33A1,PLCE1,AHCYL2,SAT2 |
Protein Function
Gpt2 has several biochemical functions, for example, L-alanine:2-oxoglutarate aminotransferase activity,pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gpt2 itself. We selected most functions Gpt2 had, and list some proteins which have the same functions with Gpt2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| L-alanine:2-oxoglutarate aminotransferase activity | GPT,GPT2L |
| pyridoxal phosphate binding | MARC1,GAD1B,PYGMA,GAD2,SPTLC3,GOT1,AGXT2L2,SPTLC2A,PROSC,AADAT |
Interacting Protein
Gpt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gpt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gpt2.
BABAM1;USP20;SIRT4
Resources
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References
- Lindblom, P; Rafter, I; et al. Isoforms of alanine aminotransferases in human tissues and serum - Differential tissue expression using novel antibodies. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 466:66-77(2007).
