Gabra2
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, alpha 2 -
Synonyms
GABRA2;gamma-aminobutyric acid (GABA) A receptor, alpha 2;gamma-aminobutyric acid receptor subunit alpha-2;GABA(A) receptor;alpha 2;GABA(A) receptor, alpha 2;GABA(A) receptor subunit alpha-2;FLJ97076
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His&GST
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
Gabra2 involved in several pathways and played different roles in them. We selected most pathways Gabra2 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gabra2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GABAergic synapse | PRKCA,GABARAPL2,SRC,GNB1,GNGT2,GNAI3,GABRB3,PLCL1,GABRQ,GABRR2 |
| Nicotine addiction | GRIN2C,GRIA1,GRIA4,GRIA3,GABRR3,GABRA1,GRIN2D,GRIN1,GABRA6,GRIN3A |
| Retrograde endocannabinoid signaling | PRKCG,GNG3,GRIA2,SLC17A6,GNB1,MAPK3,FAAH,GNB4,GABRA5,GNG10 |
| Neuroactive ligand-receptor interaction | PTH2R,NPBWR2,GABRB2,HTR4,P2RX3,NR3C1,PTGIR,LTB4R2,TSPO,F2RL1.2 |
Protein Function
Gabra2 has several biochemical functions, for example, contributes_to GABA-A receptor activity,benzodiazepine receptor activity,chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Gabra2 itself. We selected most functions Gabra2 had, and list some proteins which have the same functions with Gabra2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inhibitory extracellular ligand-gated ion channel activity | GABRG1,GABRG2,GABRA6,GABRA5,GABRB2,GABRA3,GABRA1,GABRA6A,GABRA4,GABRG3 |
| contributes_to GABA-A receptor activity | GABRP,GABRR3A,GABRA6,GABRG3,GABRG1,GABRA6A,GABRR2A,GABRZ,GABRA3,GABRA4 |
| benzodiazepine receptor activity | GABRA6,GABRA4,TSPO,GABRG2,GABRA3 |
| chloride channel activity | CLIC5,GABRE,GABRA3,GABRR3,SLC26A11,GRAP2,CLIC3,CLIC1,GABRA4,CLCA2 |
Interacting Protein
Gabra2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gabra2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gabra2.
MDM2
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References
- Jin, HB; Chiou, TT; et al. Ring Finger Protein 34 (RNF34) Interacts with and Promotes gamma-Aminobutyric Acid Type-A Receptor Degradation via Ubiquitination of the gamma 2 Subunit. JOURNAL OF BIOLOGICAL CHEMISTRY 289:29420-29436(2014).
- Takano, K; Yatabe, MS; et al. Characteristic Expressions of GABA Receptors and GABA Producing/Transporting Molecules in Rat Kidney. PLOS ONE 9:-(2014).
