GTF2B
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Official Full Name
general transcription factor IIB -
Overview
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008] -
Synonyms
GTF2B;general transcription factor IIB;TF2B;TFIIB;transcription initiation factor IIB;S300-II;general transcription factor TFIIB;RNA polymerase II transcription factor IIB
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Human
- HEK293
- HEK293T
- In Vitro Cell Free System
- E. coli
- GST
- Non
- His
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
GTF2B involved in several pathways and played different roles in them. We selected most pathways GTF2B participated on our site, such as Basal transcription factors,Epstein-Barr virus infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GTF2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | RAC1,HIST1H2BC,BAK1,STAT3,PIK3CD,H2BFWT,DDX3X,NRAS,MDM2,SND1 |
| Epstein-Barr virus infection | EIF2AK1,MDM2,PIK3CD,AKT2,MAP2K4,IRAK1,POLR2D,ITGAL,PIK3R3,CD44 |
| Basal transcription factors | GTF2A1L,TAF7L,TAF6L,GTF2A1,TBP,ERCC2,GTF2F2,TAF8,GTF2A2,GTF2H1 |
Protein Function
GTF2B has several biochemical functions, for example, core promoter binding,protein binding,thyroid hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GTF2B itself. We selected most functions GTF2B had, and list some proteins which have the same functions with GTF2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| thyroid hormone receptor binding | NUP62,THRAP3,HMGN3,NCOA3,FUS,MED13,TRIP6,MED17,MED30,ZNHIT3 |
| transcription factor binding | BCL2,EP300,DR1,HDAC4,HES3,NR0B2A,ATG7,THRA,SMARCD3,HMGB1 |
| protein binding | CD200,FBXL8,PARD6B,RPS25,PTPN11A,GP6,PTPN4,EIF4A3,RAB32,C9orf43 |
| core promoter binding | REST,ELK4,AGO1,IFI203,NOTCH1,NONO,ARNTL,CALCOCO1,SAFB,CLOCK |
| zinc ion binding | LHX6,BFAR,RNFT2,UHRF2,ZSWIM7,JADE3,TRAF6,CNOT4B,NR2C1,RANBP2 |
Interacting Protein
GTF2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GTF2B here. Most of them are supplied by our site. Hope this information will be useful for your research of GTF2B.
E2;E2;DRAP1;TNIP1;lt_sv40;NR2F1;Vdr;GTF2F2
Resources
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References
- Sayed, D; Yang, Z; et al. In Vivo Targeting Of GTF2B Selectively Inhibits Transcription Of Cardiomyopathy-related Genes And Partially Blunts Development Of Cardiac Hypertrophy. CIRCULATION RESEARCH 113:-(2013).
- Faresse, NJ; Canella, D; et al. Genomic Study of RNA Polymerase II and III SNAP(c)-Bound Promoters Reveals a Gene Transcribed by Both Enzymes and a Broad Use of Common Activators. PLOS GENETICS 8:-(2012).
