GSTT2
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Official Full Name
glutathione S-transferase, theta 2 -
Overview
Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation;of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five;main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence;identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar;structure, being composed of five exons with identical exon/intron boundaries. -
Synonyms
GSTT2;glutathione S-transferase, theta 2;glutathione S-transferase theta-2;EC 2.5.1.18;Glutathione S transferase 12;Glutathione S transferase Yrs Yrs;Glutathione S-transferase theta-2B;GST 12 12;GST class theta 2;GST class-theta-2;GST T2;GSTT 2;GSTT2 protein;GSTT2_HUMAN;GSTT2B;MGC182032;OTTHUMP00000198491;OTTHUMP00000198492;Yrs;mGSTT2;AI266894
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Rat
- Cynomolgus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- His&T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GSTT2 involved in several pathways and played different roles in them. We selected most pathways GSTT2 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | OPLAH,SRM,GPX5,ANPEP,GGT5,GSTM1,GSTM4,SMS,GGCT,GSR |
| Drug metabolism - cytochrome P | UGT1A1,ADH1,GSTP2,MGST2,UGT1A2,AOX4,ALDH3B1,GSTO1,MGST3,AOX2P |
| Metabolism of xenobiotics by cytochrome P | UGT2A3,CBR2,AKR7A2,MGST1,GSTM1,UGT2A2,HSD11B1,EPHX1,CBR1,GSTM3 |
| Chemical carcinogenesis | SULT1A4,CYP3A43,CBR1,ADH5,SULT1A3,UGT2A3,CYP2A6,ALDH3B1,GSTT1,GSTA5 |
Protein Function
GSTT2 has several biochemical functions, for example, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTT2 itself. We selected most functions GSTT2 had, and list some proteins which have the same functions with GSTT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | GSTA3,GSTA1,LTC4S,GSTT1,GSTA5,GSTM6,EEF1E1,GSTK1,GSTM5,GSTM7 |
Interacting Protein
GSTT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTT2.
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References
- Kano, S; Lo, B; et al. Altered Astrocyte-Microglia Communication as Potential Immune/Inflammatory Changes in Major Mental Illness. NEUROPSYCHOPHARMACOLOGY 39:S305-S306(2014).
- Sueblinvong, V; Tseng, V; et al. TGF beta 1 Mediates Alcohol-Induced Nrf2 Suppression in Lung Fibroblasts. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 38:2731-2742(2014).
