GSTM5
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Official Full Name
glutathione S-transferase mu 5 -
Overview
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. -
Synonyms
GSTM5;glutathione S-transferase mu 5;glutathione S transferase M5;Glutathione S alkyltransferase M5;Glutathione S aralkyltransferase M5;Glutathione S aryltransferase M5;Glutathione S transferase Mu 5;GST class mu 5;GST class-mu 5;GSTM 5;GSTM5 5;GSTM5-5;GSTM5_HUMAN;GTM 5;GTM5;OTTHUMP00000013359;OTTHUMP00000013361;S (hydroxyalkyl)glutathione lyase M5;glutathione S-transferase M5;glutathione S-aryltransferase M5;glutathione S-alkyltransferase M5;glutathione S-aralkyltransferase M5;S-(hydroxyalkyl)glutathione lyase M5
Recombinant Proteins
- Human
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
GSTM5 involved in several pathways and played different roles in them. We selected most pathways GSTM5 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | UGT1A9,CYP1B1,CYP2C50,CYP3A4,AKR1C2,CYP2E1,ALDH3B1,CYP3A25,GSTT2,GSTO2 |
| Metabolism of xenobiotics by cytochrome P | GSTA5,GSTA,ALDH3B2,GSTM,UGT2A3,CBR1L,MGST3,GSTM2,MGST1,GSTT2 |
| Glutathione metabolism | TXNDC12,GGCTA,GCLM,GPX8,GSTT2B,MGST1.2,IDH1,G6PD,GCLC,GSTT1 |
| Drug metabolism - cytochrome P | FMO5,MGST1.1,GSTM7,AOX1,GSTT2B,UGT1A6A,MGST2,UGT2A3,ALDH3A1,UGT1A6B |
Protein Function
GSTM5 has several biochemical functions, for example, glutathione transferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM5 itself. We selected most functions GSTM5 had, and list some proteins which have the same functions with GSTM5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione transferase activity | MGST2,GSTA1,GSTT2B,GSTM6,GSTA,MGST1,HPGDS,GSTP2,GSTT1B,GSTA3 |
| protein binding | UBE2B,SUPT6H,SUMO3,CNOT3,CNTNAP2,PCBD1,ARGLU1,MLH1,RAMP2,POU2AF1 |
Interacting Protein
GSTM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM5.
GSTM3;AMOTL2;PPP1CC
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References
- Yen, YK; Jiang, YW; et al. Western Blotting by Thin-Film Direct Coating. ANALYTICAL CHEMISTRY 86:5164-5170(2014).
- Iannacone, MR; Gheit, T; et al. Case-Control Study of Cutaneous Human Papillomaviruses in Squamous Cell Carcinoma of the Skin. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 21:1303-1313(2012).
