GSTM4
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Official Full Name
glutathione S-transferase mu 4 -
Overview
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. -
Synonyms
GSTM4;glutathione S-transferase mu 4;glutathione S transferase M4;Glutathione S transferase Mu 4;GST class mu 4;GST class-mu 4;GST-Mu2;GSTM4 4;GSTM4-4;GSTM4_HUMAN;GTM4;GTS Mu2;MGC131945;MGC9247;GTS-Mu2;OTTHUMP00000013356;OTTHUMP00000013358;glutathione S-transferase M4;glutathione S-aryltransferase M4;glutathione S-alkyltransferase M4;glutathione S-aralkyltransferase M4;S-(hydroxyalkyl)glutath
Recombinant Proteins
- Human
- Rhesus macaque
- Cynomolgus
- Rat
- Mouse
- E.coli
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
GSTM4 involved in several pathways and played different roles in them. We selected most pathways GSTM4 participated on our site, such as Glutathione metabolism,Metabolism of xenobiotics by cytochrome P,Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemical carcinogenesis | UGT1A9,GSTT2B,ARNT,Nat3,UGT1A2,GSTO2,UGT1A6B,ADH1,CHRNA7,CYP2C9 |
| Drug metabolism - cytochrome P | UGT2B7,UGT1A7,GSTM1,UGT1A6B,FMO4,UGT1A1,UGT1A9,AOX2P,MAOA,GSTA1 |
| Glutathione metabolism | GPX4B,GGT7,GPX3,GSTM6,MGST2,GSTM7,IDH2,GSTT1B,SMS,GSTP2 |
| Metabolism of xenobiotics by cytochrome P | GSTT1B,UGT1A7,UGT2B15,GSTT2,CBR2,GSTA5,GSTP2,GSTA3,CYP2F2,MGST2 |
Protein Function
GSTM4 has several biochemical functions, for example, enzyme binding,glutathione binding,glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM4 itself. We selected most functions GSTM4 had, and list some proteins which have the same functions with GSTM4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | DMRTC1C2,ENG,RAB11FIP4,PDE2A,RBM11,AGXT,PDCD6IP,SLC51A,RQCD1,GRPEL2 |
| protein binding | BTN2A2,TSPAN4,CENPW,KIF6,C6,PRDM13,NDUFAF3,COL1A2,GFI1B,NRG4 |
| glutathione transferase activity | GSTT1,GSTT4,MGST1,GSTK1,GSTM,EEF1E1,GSTA1,MGST3,GSTA5,GDAP1L1 |
| glutathione binding | PTGES2,GSTM3,PTGES,GPX1,GSS,GSTP2,LTC4S,GSTM7,GSTM2,GSTM1 |
| enzyme binding | PYCARD,CASC3,NPM2,MLEC,SLPI,CYP3A4,GOT2,UGT1A6,N4BP2L2,MAPT |
Interacting Protein
GSTM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM4.
GSTM3;TP53;APLP1;TLE1;ZBTB16;UNC119;RIF1;NELFCD;IGSF21;MED31
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