GSDMB
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Official Full Name
gasdermin B -
Overview
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. -
Synonyms
GSDMB;gasdermin B;gasdermin like , GSDML;gasdermin-B;PRO2521;123;156;Gasdermin like protein;Gasdermin-like protein;GSDMB_HUMAN;GSDML;PP4052;OTTHUMP00000164329;OTTHUMP00000164330;OTTHUMP00000164331;OTTHUMP00000164332;OTTHUMP00000227622
Recombinant Proteins
- Human
- Wheat Germ
- HEK293
- Mammalian cells
- E.coli
- In Vitro Cell Free System
- GST
- Non
- His&Fc&Avi
- Flag
- His&Myc
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GSDMB-4391H | Recombinant Human GSDMB Protein, GST-tagged | Wheat Germ | Human | GST |
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| GSDMB-311HCL | Recombinant Human GSDMB Lysate | HEK293 | Human | Non |
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| GSDMB-1024H | Recombinant Human GSDMB Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| GSDMB-1024H-B | Recombinant Human GSDMB Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| GSDMB-1028HFL | Recombinant Full Length Human GSDMB Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| GSDMB-1182H | Recombinant Human GSDMB protein, His&Myc-tagged | E.coli | Human | His&Myc | 1-411aa |
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| GSDMB-2354H | Recombinant Human GSDMB Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| GSDMB-3325HF | Recombinant Full Length Human GSDMB Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 411 amino acids |
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Involved Pathway
GSDMB involved in several pathways and played different roles in them. We selected most pathways GSDMB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GSDMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
GSDMB has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GSDMB itself. We selected most functions GSDMB had, and list some proteins which have the same functions with GSDMB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
GSDMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSDMB here. Most of them are supplied by our site. Hope this information will be useful for your research of GSDMB.
SERPINA1;AGT;ORM1;HIVEP1;IGFBP2;PEBP1
Resources
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References
- Acevedo, N; Reinius, LE; et al. Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus. HUMAN MOLECULAR GENETICS 24:875-890(2015).
- van der Valk, RJP; Duijts, L; et al. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134:46-55(2014).
