GRP
-
Official Full Name
gastrin-releasing peptide -
Overview
Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologues in mammals called neuromedin B and gastrin releasing peptide. It works on the gastrointestinal tract neuroendocrine hormone and it stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour. There are three different isoforms. -
Synonyms
GRP;gastrin-releasing peptide;BN;GRP-10;proGRP;preproGRP;gastrin-releasing peptide;bombesin;neuromedin C;pre-progastrin releasing peptide;OTTHUMP00000163646;OTTHUMP00000235893;OTTHUMP00000235894;OTTHUMP00000235895
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- ABP
- His
- GST
- Non
- DDK
- Myc
Involved Pathway
GRP involved in several pathways and played different roles in them. We selected most pathways GRP participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Incretin synthesis, secretion, and inactivation | DPP4,GPR120,PCSK1,O3far1,CDX2,SPCS3,GPR119,SLC38A8 |
| GPCR ligand binding | EMR2,EDNRA,TRH,PYY,NTS,EDN3,OPN5,PTGDR2,PPY,GPR37B |
| Gastrin-CREB signalling pathway via PKC and MAPK | EDN3,ABHD6B,NPSR1,LPAR2A,PROK2,NMS,HCRT,LPAR5A,EDN2,TRIO |
| GPCR downstream signaling | VIP2,RHOC,HRH3,LTB4R,ARHGAP4,APLNR,RGS7,OXGR1A.2,INSL3,SOUL4 |
| Metabolism of proteins | IGFBP4,TRAPPC10,IGF2B,NAT8,EXOC6,DHPS,F9B,PDIA6,LMCD1,VBP1 |
| Peptide hormone metabolism | SLC30A5,CMA1,CPA3,CGB7,GZMH,DPP4,GPR120,ATP6AP2,EXOC8,INHBAA |
| Class A/1 (Rhodopsin-like receptors) | UTS2,PYYA,OPN1MW2,S1PR3,APLNR,CCR7,OXGR1A.1,PENK,OPN4.1,NPSR1 |
| G alpha (q) signalling events | PROKR2,PROKR1A,TAC3,FPR-RS3,ANXA1,DGKQ,NMB,GPR4,TAE1,NMBA |
Protein Function
GRP has several biochemical functions, for example, neuropeptide hormone activity,receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRP itself. We selected most functions GRP had, and list some proteins which have the same functions with GRP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | HLA-F,ACOT2,APOF,RARRES2,MLN,TAC4,PVRL2L,NSG1,ADM,DVL3 |
| neuropeptide hormone activity | NPFFL,CALCB,POMCA,ADCYAP1,NPFF,VIP,PYYA,CCK,NTS,GAL |
Interacting Protein
GRP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRP here. Most of them are supplied by our site. Hope this information will be useful for your research of GRP.
Resources
Related Services
Related Products
References
- Andersen, B; Nielsen, KF; et al. Characterization of Alternaria strains from Argentinean blueberry, tomato, walnut and wheat. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY 196:1-10(2015).
- Er, E; Celikkan, H; et al. A new generation electrochemical sensor based on Graphene nanosheets/Gold nanoparticles/Nafion nanocomposite for determination of Silodosin. ELECTROCHIMICA ACTA 157:252-257(2015).
