GRK4
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Official Full Name
G protein-coupled receptor kinase 4 -
Overview
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. -
Synonyms
GRK4;G protein-coupled receptor kinase 4;G protein coupled receptor kinase 2 like (Drosophila) , GPRK2L;GPRK4;ITI1;IT11;GRK4a;GPRK2L
Recombinant Proteins
- Chicken
- Rat
- Zebrafish
- Mouse
- Human
- Mammalian Cell
- HEK293
- HEK293T
- E.coli
- Insect (sf21)
- Insect Cell
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
GRK4 involved in several pathways and played different roles in them. We selected most pathways GRK4 participated on our site, such as Chemokine signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | ARPC2,RAB11FIP3,D6WSU116E,CHMP1B,CXCR4A,PSD3,GRK7A,FGFR2,ARRB2B,PSD2 |
| Chemokine signaling pathway | CXCL10,GNG11,HRAS,PREX1,CCL5,CCL20,GNG3,PXN,GNG8,SHC3 |
Protein Function
GRK4 has several biochemical functions, for example, ATP binding,G-protein coupled receptor kinase activity,rhodopsin kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK4 itself. We selected most functions GRK4 had, and list some proteins which have the same functions with GRK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| rhodopsin kinase activity | GRK7A,GRK1,GRK1B,GRK7,GRK7B,GRK1A,RLN1 |
| G-protein coupled receptor kinase activity | GRK1A,GRK6,ADRBK2,GRK1,GRK7,GRK7A,GRK5,RLN1,GRK7B,GRK1B |
| ATP binding | ULK4,GRK7,RPS6KA3A,TRAP1,THG1L,UBE2N,BCR,ACTR8,NADSYN1,KIF4A |
Interacting Protein
GRK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK4.
IKBKG;HSP90AB1
GRK4 Related Signal Pathway
Resources
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References
- Furuya, Y; Araki, I; et al. Decreased expression of G protein-coupled receptor kinases in the detrusor smooth muscle of human urinary bladder with outlet obstruction. INTERNATIONAL JOURNAL OF UROLOGY 13:1226-1232(2006).
- Fraga, S; Luo, YJ; et al. Dopamine D-1-like receptor-mediated inhibition of Cl-/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6). CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 18:347-360(2006).
