GRK1
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Official Full Name
G protein-coupled receptor kinase 1 -
Overview
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). -
Synonyms
GRK1;G protein-coupled receptor kinase 1;rhodopsin kinase , RHOK;rhodopsin kinase;GPRK1;RK;RHOK
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRK1-1409H |
Active Recombinant Human GRK1, GST-tagged
|
Sf9 Insect Cell | Human | GST | Full length |
|
| GRK1-1018H | Recombinant Human G Protein-Coupled Receptor Kinase 1, GST-tagged | Sf9 Insect Cell | Human | GST |
|
|
| GRK1-2710R | Recombinant Rat GRK1 Protein | Mammalian Cell | Rat | His |
|
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| GRK1-27928TH | Recombinant Human GRK1 | Sf9 Insect Cell | Human | Non | 563 amino acids |
|
| GRK1-6261C | Recombinant Chicken GRK1 | Mammalian Cell | Chicken | His |
|
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| GRK1-5739HCL | Recombinant Human GRK1 293 Cell Lysate | HEK293 | Human | Non |
|
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| GRK1-2364R | Recombinant Rat GRK1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
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| GRK1-2364R-B | Recombinant Rat GRK1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Grk1-3311M | Recombinant Mouse Grk1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
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| GRK1-5352H | Recombinant Human GRK1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
Involved Pathway
GRK1 involved in several pathways and played different roles in them. We selected most pathways GRK1 participated on our site, such as Chemokine signaling pathway,Endocytosis,Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | GNG12,XCR1,CCL11,VAV3,PLCB2,RHOA,Cxcl15,SHC1,ADRBK1,CX3CR1 |
| Phototransduction | GNAT3,CALM,PDE6B,CALM1A,PDE6G,CALM3A,RGS9A,GRK1B,CALML3,RLN1 |
| Endocytosis | HLA-F,CLTCB,VPS37D,SPG21,CBLB,DNM3,HRAS,HLA-B,CHMP6B,BIN1B |
Protein Function
GRK1 has several biochemical functions, for example, ATP binding,G-protein coupled receptor kinase activity,protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK1 itself. We selected most functions GRK1 had, and list some proteins which have the same functions with GRK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor kinase activity | GRK1B,GRK1A,RLN1,GRK4,GRK7A,ADRBK2,GRK7B,GRK7,ADRBK1,GRK5 |
| rhodopsin kinase activity | GRK7B,GRK7,GRK7A,GRK1B,RLN1,GRK4,GRK1A |
| protein kinase activity | GM711,RIPK1L,CLK4B,MAPK14B,FGFR1A,TSSK5,ANKK1,NPR1A,KSR1,STK38A |
| ATP binding | ACVR1L,SPEG,MAP2K4B,NIM1K,SYN1,GC2,NLRP9B,TUT1,ABCC9,IP6K2 |
Interacting Protein
GRK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK1.
H2AFV
GRK1 Related Signal Pathway
Resources
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References
- Osawa, S; Jo, R; et al. Phosphorylation of GRK7 by PKA in cone photoreceptor cells is regulated by light. JOURNAL OF NEUROCHEMISTRY 107:1314-1324(2008).
- Liu, P; Osawa, S; et al. M opsin phosphorylation in intact mammalian retinas. JOURNAL OF NEUROCHEMISTRY 93:135-144(2005).
