GRIA2
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Official Full Name
glutamate receptor, ionotropic, AMPA 2 -
Overview
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GRIA2;glutamate receptor, ionotropic, AMPA 2;GLUR2;GLURB;GluA2;HBGR2;GluR-K2;glutamate receptor 2;gluR-2;gluR-B;AMPA-selective glutamate receptor 2
Recombinant Proteins
- Chicken
- Human
- Rhesus macaque
- Rat
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- Protein Conjugation
- His
- His&T7
- His&Fc&Avi
Involved Pathway
GRIA2 involved in several pathways and played different roles in them. We selected most pathways GRIA2 participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction,Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dopaminergic synapse | PPP3CA,PPP2R5C,SLC18A2,DRD3,KCNJ3,PLCB3,GNGT2,CREB5,FOS,PLCB2 |
| cAMP signaling pathway | GLI1,CREB3L3,TSHR,CREB3L2,PDE4B,RRAS,HTR1E,PIK3CB,GRIN2C,GRIA3 |
| Retrograde endocannabinoid signaling | RIMS1,GABRA4,GNG7,PLCB4,PRKCG,GNB2,GNB4,GNAO1,GNAI3,GABRA1 |
| Glutamatergic synapse | GNG4,PPP3CB,SLC17A8,GRIN2A,SLC17A7,SLC38A1,HOMER1,PLCB2,PLD1,GRM1 |
| Long-term depression | PRKG2,MAP2K1,KRAS,GNAI1,GNA11,PLCB4,HRAS,PRKCG,RAF1,LYN |
| Long-term potentiation | CALM3,MAPK1,CALML5,BRAF,PRKACB,MAP2K1,PPP3R1,CALML3,GRIN2C,ATF4 |
| Nicotine addiction | GABRA4,GABRQ,GABRP,GABRE,GABRA1,GABRA2,GRIN2D,GABRB1,GRIA3,GABRA5 |
| Amyotrophic lateral sclerosis (ALS) | TOMM40L,PPP3CA,PPP3R1,CAT,Casp3,CYCS,ALS2,MAP3K5,MAP2K6,BCL2 |
| Neuroactive ligand-receptor interaction | LHB,CRHR2,GABRA4,TACR1A,AVPR1B,F2RL2,SSTR1,NPFFR2.1,TAAR12J,GRIN2A |
Protein Function
GRIA2 has several biochemical functions, for example, AMPA glutamate receptor activity,extracellular-glutamate-gated ion channel activity,ionotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIA2 itself. We selected most functions GRIA2 had, and list some proteins which have the same functions with GRIA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular-glutamate-gated ion channel activity | GRIA3B,GRIN1A,KBP,GRIN3A,GRIN2A,GRIK5,GRIN3B,GRID1,GRIA3,GRIK4 |
| AMPA glutamate receptor activity | GRIA4,GRIA3B,GRIA2B,GRIA4B,GRIA4A,GRIA1B,GRIA2A,GRIA1,GRIA3,GRIA1A |
| ionotropic glutamate receptor activity | GRIA3B,GRIN1B,GRIA1A,GRID1,GRIN3B,GRIA4B,GRID2,GRIK3,GRIK5,GRIA3A |
| protein binding | ASIC1,HSPD1,SPHK2,SDC1,TNNT1,KLF15,HPSE,IL18,RASL11A,VIPAS39 |
Interacting Protein
GRIA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIA2.
NSF;GTF3C2;NCOA4;ECD;NDUFV3;TXNL4A;KCNAB2;ATP5F1;DPP9;POM121;TSPYL2;TRMT6
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References
- Leja, J; Essaghir, A; et al. Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. MODERN PATHOLOGY 22:261-272(2009).
