GRIA1
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Official Full Name
glutamate receptor, ionotropic, AMPA 1 -
Overview
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GRIA1;glutamate receptor, ionotropic, AMPA 1;GLUH1;GLUR1;GLURA;GluA1;HBGR1;glutamate receptor 1;AMPA 1;gluR-1;gluR-A;gluR-K1;AMPA-selective glutamate receptor 1
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- E.coli
- E. coli
- Mammalian Cell
- HEK293
- Wheat Germ
- HEK293T
- Mammalian cells
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
- His&GST
- Flag
Involved Pathway
GRIA1 involved in several pathways and played different roles in them. We selected most pathways GRIA1 participated on our site, such as cAMP signaling pathway,Neuroactive ligand-receptor interaction,Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dopaminergic synapse | CREB3L2,CAMK2B,PLCB2,SLC6A3,PPP1CB,GRIA4,PPP3CA,PRKACA,CREB3L1,GNG11 |
| Glutamatergic synapse | PLCB3,GNG3,SHANK3,PPP3CC,GNAO1,GRM7,GNG13,SLC1A2,GNAI3,SLC1A1 |
| Retrograde endocannabinoid signaling | GABRR3,GNG7,PRKCA,PLCB1,PLCB4,ABHD6,GABRA5,PRKACB,GABRR1,MAPK3 |
| Long-term depression | PRKCG,GNAI2,GRID2,GRM1,MAP2K1,PPP2R1A,MAP2K2,CRHR1,GRIA3,GNAI3 |
| Neuroactive ligand-receptor interaction | LHCGR,NPFFR2.1,SSTR1,MC3R,CSH1,ADORA1,HTR1B,CHRNB1,PRP2,ADCYAP1R1A |
| Circadian entrainment | GNGT2,GRIN2C,GNG4,CALML3,MAPK1,CALM2,GRIN2B,GNB1,PRKG1,GNAI2 |
| Nicotine addiction | GABRB2,GABRR2,GRIN2C,GABRP,GRIN1,CHRNA6,GABRR1,GRIN2A,GABRA1,GABRR3 |
| cAMP signaling pathway | NFATC1,NPY,FSHB,ROCK2,F2R,CALML3,PLCE1,HTR1B,MAPK10,GPR119 |
| Amyotrophic lateral sclerosis (ALS) | TNFRSF1A,BCL2L1,MAPK14,TOMM40,NOS1,PPP3R1,PPP3CB,MAP3K5,TP53,CASP12 |
Protein Function
GRIA1 has several biochemical functions, for example, AMPA glutamate receptor activity,PDZ domain binding,extracellular-glutamate-gated ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIA1 itself. We selected most functions GRIA1 had, and list some proteins which have the same functions with GRIA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| PDZ domain binding | GRASP,ATP2B3A,SLC26A6,SNTA1,CFTR,GJA1,SDC2,GRID2,GRIK5,ATP2B1A |
| extracellular-glutamate-gated ion channel activity | GRIK5,GRIA3A,GRIA2,GRIN1,GRIN1B,GRIA1B,GRIK4,GRIA3,GRIN3A,GRIA4 |
| glutamate receptor activity | GRM4,GRM8,GRM7,GRIK3,GRM5,GRM1,GRID2,GRM6,GRM2,GRM3 |
| AMPA glutamate receptor activity | GRIA4B,GRIA4,GRIA3B,GRIA1A,GRIA2B,GRIA3A,GRIA2A,GRIA1B,GRIA2,GRIA3 |
| protein binding | LMO1,SPSB3,MYO1E,ADAM10,ZNF572,MYH9,H2-AB1,RSPO2,NQO2,PLSCR4 |
Interacting Protein
GRIA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIA1.
PRKACA;CXCR2
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