GRB7
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Official Full Name
growth factor receptor-bound protein 7 -
Overview
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
GRB7;growth factor receptor-bound protein 7;B47;Epidermal growth factor receptor GRB 7;Epidermal growth factor receptor GRB-7;GRB7 adapter protein;GRB7_HUMAN;Growth factor receptor bound protein 7;OTTHUMP00000164349;OTTHUMP00000164350;OTTHUMP00000164351;OTTHUMP00000164352
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- DDK
- Myc
- Avi
- Fc
Involved Pathway
GRB7 involved in several pathways and played different roles in them. We selected most pathways GRB7 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling,Cell surface interactions at the vascular wall,Downstream signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hemostasis | KCNMB2,CD177,SIRPA,MAFF,KIF2B,FN1B,SLC8A2A,DOCK11,ANXA2,CD84 |
| Downstream signal transduction | PHB,AGO1,DUSP10,SPTA1,JAK1,PEBP1,FGF8B,FGF20A,FGF18B,IL17RD |
| Kit Receptor Signaling Pathway | PTPRUB,STAP1,PTPRU,DOK1B,GRB10,SOCS4,GRAPA,DOK1,GRAP,SPRED2B |
| Angiopoietin receptor Tie2-mediated signaling | BMX,GRB14,CDKN1A,DOK2,ELF2,AGTR1,ELF1,CRK |
| EPHB forward signaling | ITSN1,EFNB2,EFNB1,EFNA5,EFNB3 |
| EGFR1 Signaling Pathway | ABI1B,APPL2,RALBA,CEACAM1,MAP3K2,MTA2,SH3BGRL,TNIP1,KRT17,DNM1 |
| Cell surface interactions at the vascular wall | GLG1B,ANGPT2A,PPIA,NADL1.1,AMICA1,SLC7A6,CEACAM8,CD177,BSG,SLC3A2A |
Protein Function
GRB7 has several biochemical functions, for example, RNA binding,SH3/SH2 adaptor activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB7 itself. We selected most functions GRB7 had, and list some proteins which have the same functions with GRB7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SDK2,TMEM173,TGFB3,CD247,CHMP4A,ATG101,CTSC,GRASP,TYROBP,SNX33 |
| phosphatidylinositol binding | MTM1,ESYT2,SLC12A9,SNX6,NCF1,SNX17,ARHGAP33,FES,SNX12,SNX25 |
| RNA binding | ADAD1,PPARGC1A,APOBEC2,EIF4EA,PDCD11,UBR5,EIF2S2,SF3B3,ATXN2,HSP90B1 |
| protein kinase binding | DNM1,DCX,TP73,TP53,SYK,BCL10,CNPPD1,TRIM5,TENC1,SUFU |
| protein binding | POLR2C,ATP6V1E2,CLEC4G,CHMP1A,FAM3C,PRKD1,PLAT,FBXW2,SMYD2,IL17RE |
| SH3/SH2 adaptor activity | NCK2,KHDRBS1,PTPN11,SHB,STAM,CRKL,SOCS2,SH2D2A,GRB14,CD28 |
Interacting Protein
GRB7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB7.
ERBB2;ERBB3;KIT;RND1
GRB7 Related Signal Pathway
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References
- Murray, JC; Aldeghaither, D; et al. c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1186-1198(2014).
- Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).
