GPSM2

  • Official Full Name

    G-protein signaling modulator 2

  • Overview

    The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).

  • Synonyms

    GPSM2;G-protein signaling modulator 2;deafness, autosomal recessive 82 , DFNB82, G protein signalling modulator 2 (AGS3 like, C. elegans);G-protein-signaling modulator 2;LGN;Pins;mosaic protein LGN;G-protein signalling modulator 2 (AGS3-like, C. e

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Wheat Germ
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
GPSM2-13504H Recombinant Human GPSM2, GST-tagged E.coli Human GST N-term-353a.a.
GPSM2-10745Z Recombinant Zebrafish GPSM2 Mammalian Cell Zebrafish His
GPSM2-5765HCL Recombinant Human GPSM2 293 Cell Lysate HEK293 Human Non
GPSM2-2337H Recombinant Human GPSM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Gpsm2-3299M Recombinant Mouse Gpsm2 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
GPSM2-5300H Recombinant Human GPSM2 Protein, GST-tagged Wheat Germ Human GST
GPSM2-5564HF Recombinant Full Length Human GPSM2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 677 amino acids

    Involved Pathway

    GPSM2 involved in several pathways and played different roles in them. We selected most pathways GPSM2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GPSM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    GPSM2 has several biochemical functions, for example, GTPase regulator activity,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GPSM2 itself. We selected most functions GPSM2 had, and list some proteins which have the same functions with GPSM2. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding CEP57L1,APOA1,MCPH1,MPST,FHOD1,CRYAA,C1S,SMAD4,MNS1,KCNIP2
    protein binding RAB2A,IPO5,PUM1,BBS12,DHX38,FAM133A,TEK,TRIM22,SERTAD1,GPATCH4
    GTPase regulator activity RGS12,WASL,RUNDC3A,PCP2,TSC1,WAS,GPSM1B,TSC1A,GPSM2L,RIMS1

    Interacting Protein

    GPSM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPSM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPSM2.

    NUMA1;GNAI1;GLIS2;pins;AASDH;PABPC4L

    Resources

    References

    • Falola, MI; Wiener, HW; et al. Genomic Copy Number Variants: Evidence for Association with Antibody Response to Anthrax Vaccine Adsorbed. PLOS ONE 8:-(2013).

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