GNB5
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Official Full Name
guanine nucleotide binding protein (G protein), beta 5 -
Overview
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. -
Synonyms
GNB5;guanine nucleotide binding protein (G protein), beta 5;guanine nucleotide-binding protein subunit beta-5;GB5;FLJ37457;FLJ43714;G protein beta 5 subunit;G protein beta subunit 5L;GB 5;GBB5_HUMAN;Gbeta5;GNB 5;Guanine nucleotide binding protein (G protein) beta 5;Guanine nucleotide binding protein beta 5;Guanine nucleotide binding protein beta 5 subunit;Guanine nucleotide binding protein beta subunit 5L;Guanine nucleotide binding protein subunit beta 5;Transducin beta chain 5;OTTHUMP00000162718;G protein, beta-5 subunit;G protein, beta subunit 5L;guanine nucleotide-binding protein, beta subunit 5L
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- His&SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GNB5-13358H | Recombinant Human GNB5, GST-tagged | E.coli | Human | GST | 42-140a.a. | |
| GNB5-2604R | Recombinant Rat GNB5 Protein | Mammalian Cell | Rat | His |
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| GNB5-29091TH | Recombinant Human GNB5, His-tagged | E.coli | Human | His | Full L. 1-353 a.a. |
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| GNB5-5563C | Recombinant Chicken GNB5 | Mammalian Cell | Chicken | His |
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| GNB5-7031M | Recombinant Mouse GNB5 Protein | Mammalian Cell | Mouse | His |
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| GNB5-5859HCL | Recombinant Human GNB5 293 Cell Lysate | HEK293 | Human | Non |
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| GNB5-2259R | Recombinant Rat GNB5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| GNB5-2259R-B | Recombinant Rat GNB5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GNB5-2978H | Recombinant Human GNB5 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 1-353aa |
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| GNB5-3769M | Recombinant Mouse GNB5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GNB5-3769M-B | Recombinant Mouse GNB5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GNB5-5058H | Recombinant Human GNB5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GNB5-5372HF | Recombinant Full Length Human GNB5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 126 amino acids |
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Involved Pathway
GNB5 involved in several pathways and played different roles in them. We selected most pathways GNB5 participated on our site, such as ADP signalling through P2Y purinoceptor 1,ADP signalling through P2Y purinoceptor 12,Activation of Kainate Receptors upon glutamate binding, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | HIST1H2AD,SHC3,HIST1H2BO,HIST1H4G,GNG2,HIST2H4,H2AFB3,HDAC3,H2AFB1,PRKACA |
| ADP signalling through P2Y purinoceptor 1 | MAPK14 |
| Aquaporin-mediated transport | PRKAR1AA,MIPA,AQP1A.1,MYO5B,AQP6,AQP10,ADCY6,GNB3A,GNB5A,AQP3B |
| Adrenaline,noradrenaline inhibits insulin secretion | GNB5B,GNB5A,ADRA2A,GNB3A,ADCY6,ADRA2C,GNB3B |
| Activation of Kainate Receptors upon glutamate binding | DLG3,DLG4,DLG1L,NCALDA |
| Beta-catenin independent WNT signaling | DVL2,ROR2,PRICKLE1B,AGO2,CLTB,DVL1,ITPR2,CLTA,MOV10,RYK |
| Ca2+ pathway | AGO2,MOV10,AGO1,AGO3 |
Protein Function
GNB5 has several biochemical functions, for example, G-protein gamma-subunit binding,GTPase activity,chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB5 itself. We selected most functions GNB5 had, and list some proteins which have the same functions with GNB5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activity | TUBA7L,RAB38,IFT22,NKIRAS1,RAB42B,TUBA8L3,TUBB4B,RHOU,EEF2A.1,ARL8B |
| signal transducer activity | OLFR181,OLFCG4,GNGT2A,JUP,GNB1A,GNG13B,TAAR12F,STAT2,GNG2,TAAR10D |
| protein binding | BLVRA,SOX15,GSN,PPM1B,SLC30A2,TMED10,BCL2L16,WDR77,PPIL1,RAN |
| chaperone binding | CDC37,SERPINA7,USP13,CP,ATP1A3,DNAJA3B,ATP1A2,HSCB,PACRG,DLST |
Interacting Protein
GNB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB5.
a8k1f4_human;GNG7;STIP1;MLF1;PSMD2;Usp19;HSP90AB1;q96be0_human;PFDN5;DNAJC7;AARSD1;PFDN2;NUDC;PSD;BNIP3L;EIF3J;OLFM2;ANXA7;RPA1;CDKN1A
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References
- Fang, LT; Lee, S; et al. Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis. INTERNATIONAL JOURNAL OF ONCOLOGY 44:211-221(2014).
- Chen, YY; Zhou, CX; et al. Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 385:797-806(2012).
