GNB4
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Official Full Name
guanine nucleotide binding protein (G protein), beta polypeptide 4 -
Overview
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. -
Synonyms
GNB4;guanine nucleotide binding protein (G protein), beta polypeptide 4;guanine nucleotide-binding protein subunit beta-4;G protein beta 4 subunit;GNB 4;Guanine nucleotide binding protein (G protein) beta polypeptide 4;Guanine nucleotide binding protein beta 4 subunit;Guanine nucleotide binding protein beta polypeptide 4;Guanine nucleotide binding protein beta subunit 4;Guanine nucleotide binding protein subunit beta 4;Transducin beta chain 4;G protein beta-4 subunit
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- T7
- His
- Non
- His&Fc&Avi
Involved Pathway
GNB4 involved in several pathways and played different roles in them. We selected most pathways GNB4 participated on our site, such as Ras signaling pathway,Chemokine signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Retrograde endocannabinoid signaling | GNB1,GABRG2,PTGS2,MAPK10,PRKACB,GABRA2,GABRB3,PRKCA,ITPR1,GABRA4 |
| Circadian entrainment | GRIN2D,GNB1,GNG5,PRKCG,NOS1AP,GNGT1,CALM4,GUCY1B3,GNG2,PRKACB |
| Serotonergic synapse | CYP2C38,CYP2D26,TPH2,SLC18A2,GABRB2,HTR4,PRKCA,HTR3B,PRKCG,PRKACB |
| Alcoholism | HIST1H4F,GNAI3,HIST1H3C,GNG13,HRAS,HIST1H2BO,GNG4,CAMKK2,HIST1H4G,GNB2 |
| GABAergic synapse | GABRA2,GABRR3,GABRA5,GABARAPL2,SLC38A2,GPHN,GNAI3,GNB1,SLC6A13,GNG3 |
| Cholinergic synapse | GNGT1,KCNJ4,PLCB3,GNG4,PRKCA,KCNJ12,GNA11,GNAI2,GNG11,GNG8 |
| PIK-Akt signaling pathway | INS,AKT2,Itga10&Itgb1,STK11,PDGFD,GNG11,TLR4,PPP2CA,G6PC2,PPP2R2C |
| Glutamatergic synapse | GNB3,SLC1A2,GNAQ,PRKACA,SLC17A7,GRIK5,GRIN1,GNGT1,GNG13,PRKACB |
| Dopaminergic synapse | GNGT2,CREB3L4,PLCB4,MAPK8,CALM1,PPP2R5E,PPP2R2B,CALY,GNB2,PPP2R5C |
Protein Function
GNB4 has several biochemical functions, for example, protein complex binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB4 itself. We selected most functions GNB4 had, and list some proteins which have the same functions with GNB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | LRP2,GRIN2A,KAT2B,IST1,FADD,CD2AP,PDZK1,INS2,HSPD1,GNB1 |
| signal transducer activity | DRD4-RS,MGAA,CBL,OLFCH1,CAPN3,GNG7,PTK2BB,CCR1L1,GNAS,MUL1 |
Interacting Protein
GNB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB4.
Cdk1;Trim69;Haus4;Haus1;q96be0_human;PFDN5;Mau2;q9hav2_human;FKBPL;NUDC;RIPK3;ESR1;NS;ERBB2;MTNR1A;MTNR1B;CDK18;Myh10
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References
- Liu, L; Zhang, RX; et al. Intermediate Charcot-Marie-Tooth disease. NEUROSCIENCE BULLETIN 30:999-1009(2014).
- Baets, J; De Jonghe, P; et al. Recent advances in Charcot-Marie-Tooth disease. CURRENT OPINION IN NEUROLOGY 27:532-540(2014).
