GNB2

  • Official Full Name

    guanine nucleotide binding protein (G protein), beta polypeptide 2

  • Overview

    Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5 UTR.

  • Synonyms

    GNB2;guanine nucleotide binding protein (G protein), beta polypeptide 2;guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;G protein;beta 2 subunit;guanine nucleotide binding protein G(I)/G(S)/G(T) beta subunit 2;signal transducing gua

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Non
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GNB2-13355H Recombinant Human GNB2, His-tagged E.coli Human His 1-340a.a.
GNB2-2167Z Recombinant Zebrafish GNB2 Mammalian Cell Zebrafish His
GNB2-2601R Recombinant Rat GNB2 Protein Mammalian Cell Rat His
GNB2-7027M Recombinant Mouse GNB2 Protein Mammalian Cell Mouse His
GNB2-5863HCL Recombinant Human GNB2 293 Cell Lysate HEK293 Human Non
GNB2-2256R Recombinant Rat GNB2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
GNB2-2256R-B Recombinant Rat GNB2 Protein Pre-coupled Magnetic Beads HEK293 Rat
GNB2-3346H Recombinant Human GNB2 Protein (Ser2-Asn340), N-His tagged E.coli Human His Ser2-Asn340
GNB2-3766M Recombinant Mouse GNB2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
GNB2-3766M-B Recombinant Mouse GNB2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GNB2-5054H Recombinant Human GNB2 Protein, GST-tagged Wheat Germ Human GST
GNB2-5215H Recombinant Human GNB2 protein, GST-tagged E.coli Human GST 21-327aa
GNB2-5358HF Recombinant Full Length Human GNB2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 340 amino acids

    Involved Pathway

    GNB2 involved in several pathways and played different roles in them. We selected most pathways GNB2 participated on our site, such as Ras signaling pathway,Chemokine signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cholinergic synapse CREB5,GNG10,CHRNB4,JAK2,GNGT2,CAMK2G,KCNQ4,CAMK2A,PIK3CG,BCL2
    Circadian entrainment GNG11,CAMK2B,ADCYAP1R1,GNB3,GRIA4,GNAI3,RYR1,KCNJ5,PER3,CALM4
    Serotonergic synapse Casp3,GNAQ,CYP4X1,PLCB2,MAP2K1,CYP2D10,ALOX5,CYP2C38,GNG2,PLCB4
    Pathways in cancer CUL2,ITGA3,ERBB2,TRAF6,RELA,FZD10,BIRC5,BCR,PPARG,BMP2
    Alcoholism HIST1H2BD,CAMKK2,HIST1H2AI,HIST2H3C2,GRIN2B,SOS1,BRAF,HIST1H2AJ,GNB1,HIST2H2AA2
    Retrograde endocannabinoid signaling MAPK9,GRM1,NAPEPLD,MAPK13,GABRG2,PLCB1,GABRR2,ITPR1,GNGT2,MAPK3
    Chemokine signaling pathway RELA,CRK,CCL22,CCL3,GNGT1,GNG5,ARRB2,STAT5B,AKT1,GRK7
    Ras signaling pathway GAB2,INS1,MAPK10,CALML3,IGF1R,RAF1,FOXO4,PAK3,GNG10,GRIN2A
    GABAergic synapse SLC6A13,GLS2,GNG3,GABRR3,PRKCA,SLC38A5,GNG11,GABRA2,GNG8,SRC

    Protein Function

    GNB2 has several biochemical functions, for example, GTPase activity,GTPase binding,calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GNB2 itself. We selected most functions GNB2 had, and list some proteins which have the same functions with GNB2. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activity ATL1,RALBA,RAB3AA,GNL3,RAB11A,RAB18,GNA11,GNL1,MFN2,GNAI2B
    protein binding MCM3,BCAR3,ZBTB43,NFYC,FAM167A,DENR,DCAF11,SCRT1,HPCAL4,RAB11FIP2
    signal transducer activity TRIM54,GPR132,TAS2R109,PTGER1C,CHKA,TRHRB,TAS2R113,OLFR151,PTGER1B,PRMT2
    protein complex binding ING2,ARRB2,VAMP2,CRIPT,TXN2,TULP3,FLCN,PTCH1,LZTFL1,Casp3
    GTPase binding GNB3,RAB3D,AIMP1,EPRS,STOML2,YBX1,HSP90AA1,GNB1,IARS,GM5506
    calcium channel regulator activity STIM2,STIM1A,CACNA2D3,SGK2B,STIM1,CRISP1,CACNA2D4,NRXN2,TMEM110,GRM6A

    Interacting Protein

    GNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNB2.

    Cdk1;Cbx1;Cep76;IKBKE;USP50;Trim69;Haus4;Haus1;MAP3K3;Mau2;TRAF6;RIPK3;CAPNS1;TFAP2A;PDHB;RCC1;ANXA7;GADD45A;CDKN1A;STAT5A

    Resources

    References

    • Xing, T; Higgins, VJ; et al. Identification of G proteins mediating fungal elicitor-induced dephosphorylation of host plasma membrane H+-ATPase. JOURNAL OF EXPERIMENTAL BOTANY 48:229-237(1997).
    • Joshi, S; Abebe, W; et al. G-proteins in guinea pig airway smooth muscle: Identification and functional involvement. PHARMACOLOGICAL RESEARCH 33:195-202(1996).
    • LIU, JJ; MCLENNAN, AG; et al. PURIFICATION AND PROPERTIES OF GTP-GTP GUANYLYLTRANSFERASE FROM ENCYSTED EMBRYOS OF THE BRINE SHRIMP ARTEMIA. JOURNAL OF BIOLOGICAL CHEMISTRY 269:11787-11794(1994).

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