GNAO1
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Official Full Name
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -
Overview
Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP. -
Synonyms
Goα-Subunit;Gnao1;guanine nucleotide binding protein, alpha O;Gnao;alphaO;Galphao;AW050213;Guanine nucleotide binding protein G(o) subunit alpha;Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O;DKFZp686O0962;G-ALPHA-o;G alpha o;G protein alpha 0;GNAO 1;Go alpha;Guanine nucleotide binding protein (G pro-tein) alpha activating activity polypeptide O;Guanine nucleotide binding protein alpha activating polypeptide;OT-THUMP00000164318;OTTHUMP00000164319
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GNAO1 involved in several pathways and played different roles in them. We selected most pathways GNAO1 participated on our site, such as Rap signaling pathway,Circadian entrainment,Retrograde endocannabinoid signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | H2AFB2,FOSB,CAMK4,HDAC6,DRD1,HIST1H2AO,HIST1H2AL,HDAC8,HIST1H2AF,GNB5 |
| Chagas disease (American trypanosomiasis) | CFLAR,MAPK10,GNAS,TNF,GNAI3,MAPK3,IFNGR2,MAPK11,CD247,IL12B |
| Oxytocin signaling pathway | PRKAG3,RYR3,PLA2G4A,SRC,PRKAA1,GNAS,HRAS,CACNA2D1,PIK3R2,OXT |
| Serotonergic synapse | GNB3,HTR3C,ALOX8,GABRB3,ITPR3,GABRB2,HTR6,SLC18A1,HTR2B,ALOX15 |
| GABAergic synapse | GABRQ,GABRR3,GNG11,GNG3,GABRG1,GPHN,GNG4,SLC6A13,GAD1,GNG13 |
| Circadian entrainment | GNAI1,CACNA1G,GNB4,Adcy4,KCNJ5,GRIN2C,AKR1C1,GNG4,MAPK1,GNG11 |
| Rap signaling pathway | PRKCG,GRIN1,RAPGEF5,PGF,KRAS,FGF5,SRC,GNAQ,NGF,CALML3 |
| Estrogen signaling pathway | PIK3CD,HSP90AA1,HRAS,PRKCD,FOS,CREB3L2,HSPA6,ESR1,PIK3R5,CREB3L3 |
| Cholinergic synapse | PIK3CG,PRKACG,GNA11,CHRNA7,PLCB3,CHRM4,JAK2,MAPK1,KCNJ12,GNGT2 |
Protein Function
GNAO1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,G-protein coupled serotonin receptor binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAO1 itself. We selected most functions GNAO1 had, and list some proteins which have the same functions with GNAO1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | POLR2B,ZBTB14,POMT1,CYP2C38,NANOS1,KCNIP3A,ZDHHC16B,Gh,MAZ,SP5 |
| GTPase activity | RAC2,TUBA3C,TUBA8L4,OPA1,EEF1A1,TUBB2,GBP1,RIT2,GNA15.4,RAB43 |
| corticotropin-releasing hormone receptor 1 binding | GNAO1B,UCN,CRH,GNAO1A,GNAS |
| GTP binding | EIF2B2,GMPPB,GNAI2,RALB,TUBA1A,RAB39B,RNGTT,ACSM1,RHOC,RAB11BA |
| G-protein coupled serotonin receptor binding | GNAIA,GNAO1B,GNAZ,GNAI3,GNAO1A,GNAI1 |
| mu-type opioid receptor binding | GNAO1B,FLNA,GNAS,GNAO1A,GPR177,WLS |
| GTPase activating protein binding | CDH1,FMNL1,RGS14,PTBP3,TUBB,PIN1,PLCD1,GNAI3,MEX3B,GNAI1 |
| G-protein beta/gamma-subunit complex binding | GNAI3,GNAT1,GNAI2A,GNA12,GNAI2,CETN2,GNAO1A,GNAQ,GNA11B,GNAL |
| signal transducer activity | VMN1R45,SHC3,VMN1R52,CRKL,TFG,LSP1,PLCB1,TAAR9,DKKL1,TMTOPS3B |
Interacting Protein
GNAO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAO1.
gtp;APP;CXCR5;Haus4;DCTN2;15-deoxy-delta(12,14;HTT
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References
- Zupancic, K; Blejec, A; et al. Identification of plasma biomarker candidates in glioblastoma using an antibody-array-based proteomic approach. RADIOLOGY AND ONCOLOGY 48:257-266(2014).
