GLRA1

  • Official Full Name

    glycine receptor, alpha 1

  • Overview

    The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates;postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE),;also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different;isoforms have been found for this gene.

  • Synonyms

    GLRA1;glycine receptor, alpha 1;glycine receptor, alpha 1 (startle disease/hyperekplexia) , STHE;glycine receptor subunit alpha-1;startle disease/hyperekplexia;stiff person syndrome;glycine receptor 48 kDa subunit;glycine receptor strychnine-bindin

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
  • N-His&C-Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
GLRA1-13307H Recombinant Human GLRA1, GST-tagged E.coli Human GST 27-250a.a.
GLRA1-1871R Recombinant Rhesus monkey GLRA1 Protein, His-tagged Mammalian Cell Rhesus macaque His
GLRA1-2567R Recombinant Rat GLRA1 Protein Mammalian Cell Rat His
GLRA1-27289TH Recombinant Human GLRA1 Wheat Germ Human Non 100 amino acids
GLRA1-8975Z Recombinant Zebrafish GLRA1 Mammalian Cell Zebrafish His
GLRA1-712HCL Recombinant Human GLRA1 cell lysate Human Non
GLRA1-1691R Recombinant Rhesus Macaque GLRA1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
GLRA1-1691R-B Recombinant Rhesus Macaque GLRA1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
GLRA1-2222R Recombinant Rat GLRA1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
GLRA1-2222R-B Recombinant Rat GLRA1 Protein Pre-coupled Magnetic Beads HEK293 Rat
GLRA1-4344H Recombinant Human GLRA1 protein, His&Myc-tagged E.coli Human N-His&C-Myc 29-250aa
GLRA1-4970H Recombinant Human GLRA1 Protein, GST-tagged Wheat Germ Human GST
GLRA1-5343HF Recombinant Full Length Human GLRA1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 449 amino acids

    Involved Pathway

    GLRA1 involved in several pathways and played different roles in them. We selected most pathways GLRA1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction PRL,GABRA4,GRIA4B,SSTR4,GLRA2,GRM1,GNRHR1,TAAR1,GRID1,P2RX8

    Protein Function

    GLRA1 has several biochemical functions, for example, extracellular-glycine-gated chloride channel activity,contributes_to extracellular-glycine-gated chloride channel activity,glycine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLRA1 itself. We selected most functions GLRA1 had, and list some proteins which have the same functions with GLRA1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PPP4R4,ELF3,C8orf4,CHRNB2,TMIGD2,ARSA,MED7,NFKBIZ,FANCD2,NR1H3
    contributes_to extracellular-glycine-gated chloride channel activity GLRA3,GLRA4B,GLRB,GLRBA
    taurine binding SLC6A6
    extracellular-glycine-gated chloride channel activity GLRA4A,GLRBA,SIX2A,GLRB,GLRA2,GLRBB
    transmitter-gated ion channel activity GLRA3,SIX2A,GLRA4B,GLRA4A,GLRA2
    glycine binding GRIN1,SIX2A,GLRA4B,GRIN3B,GRIN2B,GSS,GLDC,ALAS2,GLRA2,SRR

    Interacting Protein

    GLRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLRA1.

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