GLIPR1
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Official Full Name
GLI pathogenesis-related 1 -
Overview
This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. -
Synonyms
GLIPR1;GLI pathogenesis-related 1;GLI pathogenesis related 1 (glioma);glioma pathogenesis-related protein 1;GliPR;RTVP1;CRISP 7;CRISP7;GLI pathogenesis related 1;GLI pathogenesis-related 1 (glioma);Glioma pathogenesis related protein 1;GLIP1_HUMAN;GliPR 1;Protein RTVP-1;RELATED TO TESTIS SPECIFIC, VESPID, AND PATHOGENESIS PROTEINS 1;RTVP 1;Testes specific vespid and pathogenesis protein 1;testes-specific vespid and pathogenesis protein 1;related to testis-specific, vespid, and pathogenesis proteins 1
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mus musculus
- Human Cells
- Mammalian Cells
- HEK293
- E.coli
- Wheat Germ
- His
- Non
- Avi&His&Fc
- GST
Involved Pathway
GLIPR1 involved in several pathways and played different roles in them. We selected most pathways GLIPR1 participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLIPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fatty acid, triacylglycerol, and ketone body metabolism | CPT2,PPARGC1B,ACOT10,AGPAT2,ECI1,SLC25A1,APOA5,ACSF2,MED8,STIL |
| Metabolism | PPM1L,NAT2,APOEB,PPARGC1B,AKR1C6,ACOT9,COX15,PFKLB,COX10,PIK3R6 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | MED20,ANKRD1,MED19,GRHL1,MED7,MED22,MED10,MED6,MED9,MED29 |
| PPARA activates gene expression | MED6,G0S2,MED25,MED29,MED10,MED15,PLIN2,GRHL1,MED20,MED9 |
| Metabolism of lipids and lipoproteins | CYP4F11,NFYAL,FAM213B,APOF,SCP2B,CYP2Y3,PITPNB,CYP4T8,CYP46A1,MTP |
Protein Function
GLIPR1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by GLIPR1 itself. We selected most functions GLIPR1 had, and list some proteins which have the same functions with GLIPR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
GLIPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLIPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLIPR1.
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References
- Zhang, L; Yang, B; et al. Potential therapeutic mechanism of genistein in breast cancer involves inhibition of cell cycle regulation. MOLECULAR MEDICINE REPORTS 11:1820-1826(2015).
- Chakrabarti, S; Multani, S; et al. Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study. MEDICAL ONCOLOGY 32:-(2015).
