GLE1
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Official Full Name
GLE1 RNA export mediator homolog -
Overview
This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GLE1;GLE1 RNA export mediator homolog (yeast);GLE1 (yeast homolog) like, RNA export mediator , GLE1 RNA export mediator (yeast) , GLE1 RNA export mediator like (yeast) , GLE1L, LCCS1, lethal congenital contracture syndrome 1;nucleoporin GLE1;hGLE1
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
GLE1 involved in several pathways and played different roles in them. We selected most pathways GLE1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GLE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
GLE1 has several biochemical functions, for example, identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GLE1 itself. We selected most functions GLE1 had, and list some proteins which have the same functions with GLE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SMARCD1,STON2,TNIP3,LAMTOR1,IGF1,CECR2,PRICKLE1,BCL7A,CD5,DPPA4 |
| identical protein binding | FBP1,ATL1,CEP170L,GLUL,PLEKHH2,TPRGL,IFI203,SNX8,ALS2CL,CLDN15 |
Interacting Protein
GLE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GLE1.
EIF3F;PRT1;NUP155;KTN1;NUP153;NUP107;Ube2i;KPNB1;Nup98;Nup107;SEH1L;Ranbp2
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References
- Kaneb, HM; Folkmann, AW; et al. Deleterious mutations in the essential mRNA metabolism factor, hGle1, in amyotrophic lateral sclerosis. HUMAN MOLECULAR GENETICS 24:1363-1373(2015).
- Ellard, S; Kivuva, E; et al. An exome sequencing strategy to diagnose lethal autosomal recessive disorders. EUROPEAN JOURNAL OF HUMAN GENETICS 23:401-404(2015).
