GJB3
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Official Full Name
gap junction protein, beta 3, 31kDa -
Overview
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are;composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials;from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin;disorder. Alternative splicing results in multiple transcript variants encoding the same protein. -
Synonyms
GJB3;gap junction protein, beta 3, 31kDa;DFNA2, EKV, erythrokeratodermia variabilis , gap junction protein, beta 3, 31kD (connexin 31) , gap junction protein, beta 3, 31kDa (connexin 31);gap junction beta-3 protein;connexin 31;CX31;connexin-31;E
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- Bovine
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
GJB3 involved in several pathways and played different roles in them. We selected most pathways GJB3 participated on our site, such as Calcium Regulation in the Cardiac Cell,Gap junction assembly,Gap junction trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with GJB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gap junction assembly | GJB5,GJA4,GJA8,GJB2,GJD3,GJB7,CX30.3,GJB4,GJA5,GJC1 |
| Vesicle-mediated transport | MYO1C,SNF8,FTH1A,STXBP3,COPB1,TRAPPC2L,RALAA,TPD52,BLOC1S6,MIA3 |
| Calcium Regulation in the Cardiac Cell | YWHAQ,CASQ1,ADRa1A,RGS7,GJB2,AKR1C1,KCNJ3,RGS16,RGS19,GJC2 |
| Gap junction trafficking | MYO6A,MYO6,GJD3,GJC1,GJA5,GJA8,MYO6B,GJB5,GJB2,CX27.5 |
| Gap junction trafficking and regulation | GJC1,CX27.5,GJA4,MYO6,DAB2,MYO6B,CX30.3,GJA8,GJB4,GJB5 |
| Membrane Trafficking | SEC23IP,NSFB,COPE,COPB1,RAB10,GJB7,GAK,ANKRD28,PPP6R3,TCEAL4 |
Protein Function
GJB3 has several biochemical functions, for example, gap junction channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GJB3 itself. We selected most functions GJB3 had, and list some proteins which have the same functions with GJB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| gap junction channel activity | GJA10,CX52.6,GJA1,GJA8,PANX2,CX43,GJD3,CX23,GJB2,GJC1 |
Interacting Protein
GJB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GJB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GJB3.
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