GIT1
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Official Full Name
G protein-coupled receptor kinase interacting ArfGAP 1 -
Overview
ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene. -
Synonyms
GIT1;G protein-coupled receptor kinase interacting ArfGAP 1;G protein coupled receptor kinase interactor 1;ARF GTPase-activating protein GIT1;CAT1;CAT-1;ARF GAP GIT1;GRK-interacting protein 1;G protein-coupled receptor kinase interactor 1;G prote
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- GST
- Myc&DDK
Involved Pathway
GIT1 involved in several pathways and played different roles in them. We selected most pathways GIT1 participated on our site, such as Endocytosis,Regulation of actin cytoskeleton,Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with GIT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epithelial cell signaling in Helicobacter pylori infection | MAPK13,NFKB1,CXCR2,IKBKG,MAPK12,TCIRG1,MAP3K14,ATP6V0C,MAPK11,PLCG2 |
| Regulation of Actin Cytoskeleton | ITGA11A,PIP4K2AA,RAC1B,KRAS,APC2,ITGB4,FGF11,ACTN3,PXNA,ITGA2B |
| Endocytosis | ARRB2A,ARF3,IL2RB,CHMP2BA,ERBB3,IL2RGB,ARPC4,EHD1,PARD6GA,HLA-B |
Protein Function
GIT1 has several biochemical functions, for example, GTPase activator activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GIT1 itself. We selected most functions GIT1 had, and list some proteins which have the same functions with GIT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | TULP3,NCKAP1L,NR0B2,CD2AP,HTR2A,CPS1,RANBP2,BRK1,FBLN1,NSF |
| metal ion binding | CRBN,GUCA1B,ZNF32,MGAT4C,UNC13A,FYN,RBM4.2,SCD5,PPP3CC,ZNF461 |
| GTPase activator activity | ARHGAP22,TBC1D7,SGSM2,RGS9,CHN2,TBC1D30,RGS4,AXIN1,DOCK4,PLEKHG6 |
| protein binding | RBP4,ZNF32,WBSCR27,NUDT1,UBA2,HERC5,NUBP2,BCDIN3D,MT1H,SP1 |
Interacting Protein
GIT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GIT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GIT1.
ARHGEF7;PAK1;PAK2;HTT
Resources
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References
- Fujikawa, A; Matsumoto, M; et al. Specific Dephosphorylation at Tyr-554 of Git1 by Ptprz Promotes Its Association with Paxillin and Hic-5. PLOS ONE 10:-(2015).
- Hammer, A; Oladimeji, P; et al. Phosphorylation of tyrosine 285 of PAK1 facilitates beta PIX/GIT1 binding and adhesion turnover. FASEB JOURNAL 29:943-959(2015).
