GGH
-
Official Full Name
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -
Overview
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of;gamma-linked polyglutamates and glutamate. -
Synonyms
GGH;gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase);gamma-glutamyl hydrolase;gamma-Glu-X carboxypeptidase;GH
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Myc&DDK
- Non
- N-His-GST&C-Myc
- His&Fc&Avi
Involved Pathway
GGH involved in several pathways and played different roles in them. We selected most pathways GGH participated on our site, such as Folate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Folate biosynthesis | ALPP,DHFR,QDPRB2,ALPL,MOCS1,DHFRL1,GCH1,ALP3,QDPR,ALPI.1 |
Protein Function
GGH has several biochemical functions, for example, exopeptidase activity,gamma-glutamyl-peptidase activity,omega peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GGH itself. We selected most functions GGH had, and list some proteins which have the same functions with GGH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| exopeptidase activity | MME,ACE |
| omega peptidase activity | ATXN3,UCHL1,USP5,APEH,USP13,JOSD1,ATXN3L,UCHL5,JOSD2 |
Interacting Protein
GGH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGH here. Most of them are supplied by our site. Hope this information will be useful for your research of GGH.
ATP6V1A;MAP1LC3B
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References
- Hoang, PTV; Ambroise, J; et al. Comparative pharmacogenetic analysis of risk polymorphisms in Caucasian and Vietnamese children with acute lymphoblastic leukemia: prediction of therapeutic outcome?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 79:429-440(2015).
- Kim, SE; Hinoue, T; et al. gamma-Glutamyl hydrolase modulation significantly influences global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells. GENES AND NUTRITION 10:-(2015).
