GGA2
-
Official Full Name
golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -
Overview
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. -
Synonyms
GGA2;golgi-associated, gamma adaptin ear containing, ARF binding protein 2;ADP-ribosylation factor-binding protein GGA2;KIAA1080;VEAR;ARF-binding protein 2;gamma ear-containing;1200007E24Rik;ADP ribosylation factor binding protein 2;ADP ribosylation factor binding protein GGA 2;ADP ribosylation factor binding protein GGA2;FLJ20966;Gamma adaptin related protein 2;Gamma-adaptin related protein 2;Gamma-adaptin-related protein 2;GGA 2;GGA2_HUMAN;Golgi associated gamma adaptin ear containing ARF binding protein 2;Golgi localized gamma ear containing ARF binding protein 2;Golgi-localized;VHS domain and ear domain containing protein;VHS domain and ear domain of gamma adaptin;VHS domain and ear domain of gamma-adaptin;VHS domain and ear domain-containing protein;golgi-localized, gamma ear-containing, ARF-binding protein 2;golgi associated, gamma adaptin ear containing, ARF binding protein 2
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GGA2-6323M | Recombinant Mouse GGA2 Protein | Mammalian Cells | Mouse | His |
|
|
| GGA2-5950HCL | Recombinant Human GGA2 293 Cell Lysate | HEK293 | Human | Non |
|
|
| Gga2-3198M | Recombinant Mouse Gga2 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
|
|
| GGA2-3542M | Recombinant Mouse GGA2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| GGA2-3542M-B | Recombinant Mouse GGA2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
||
| GGA2-4866H | Recombinant Human GGA2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| GGA2-5452HF | Recombinant Full Length Human GGA2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 613 amino acids |
|
Involved Pathway
GGA2 involved in several pathways and played different roles in them. We selected most pathways GGA2 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | ENTPD4,ACP5,HEXA,LIPA,Ctsl,CLN3,CTSE,NPC2,ARSG,SUMF1 |
Protein Function
GGA2 has several biochemical functions, for example, ADP-ribosylation factor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GGA2 itself. We selected most functions GGA2 had, and list some proteins which have the same functions with GGA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ADP-ribosylation factor binding | SORL1,RAB11FIP4A,RAB11FIP3,RAB11FIP4,GGA3,ZFP652,RAB11FIP4B,ADCYAP1R1,GRASP |
| protein binding | AP2B1,TUB,CANX,DNAJB5,SIX1,ABCA1,KATNBL1,PITX2,CHMP2B,SIN3A |
Interacting Protein
GGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GGA2.
RABEP1;SORT1;CLTC;CA8;IGF2R;ARF1
Resources
Related Services
Related Products
References
- Sun, YF; Liu, RR; et al. Genome-Wide Linkage Analysis and Association Study Identifies Loci for Polydactyly in Chickens. G3-GENES GENOMES GENETICS 4:1167-1172(2014).
- Doray, B; Govero, J; et al. Impact of Genetic Background on Neonatal Lethality of Gga2 Gene-Trap Mice. G3-GENES GENOMES GENETICS 4:885-890(2014).
