GFPT2
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Official Full Name
glutamine-fructose-6-phosphate transaminase 2 -
Overview
GFAT1, glutamine:fructose-6-phosphate aminotransferase 1, is the rate-limiting enzyme of the hexosamine biosynthesis pathway (1). This enzyme catalyzes the conversion of fructose-6-phosphate and glutamine to glucosamine-6-phosphate and glutamate (2). The -
Synonyms
GFPT2;glutamine-fructose-6-phosphate transaminase 2;glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2;GFAT2;glutamine: fructose 6 phosphate aminotransferase 2;GFAT 2;hexosephosphate aminotransferase 2;D-fructose-6-phosphate amidotr
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His&T7
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
GFPT2 involved in several pathways and played different roles in them. We selected most pathways GFPT2 participated on our site, such as Alanine, aspartate and glutamate metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFPT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alanine, aspartate and glutamate metabolism | ALDH5A1,GPT,RIMKLA,ADSSL,GLUD2,GLS,GLUD1,PPAT,ASL,CAD |
| Amino sugar and nucleotide sugar metabolism | HEXB,FUK,NANP,CYB5RL,PGM1,UGDH,NANS,GPIB,CMASA,GNE |
| Metabolic pathways | GALNT2,PFKMB,MBOAT1,ST6GALNAC3,HLCS,NAPRT1,CBR2,POLE2,ACSL1,POLR2C |
| Insulin resistance | AKT2L,PRKCBA,PPP1CB,PTPRF,MTOR,PIK3CB,INSR,PPP1R3CA,G6PC2,TRIB3 |
Protein Function
GFPT2 has several biochemical functions, for example, carbohydrate binding,glutamine-fructose-6-phosphate transaminase (isomerizing) activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFPT2 itself. We selected most functions GFPT2 had, and list some proteins which have the same functions with GFPT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutamine-fructose-6-phosphate transaminase (isomerizing) activity | GFPT1 |
| carbohydrate binding | LGALS8,LGALS2A,KLRB1,SIGLEC11,MAN2B2,GALNT5,ATRNL1,CD69,KLRD1,Fcer2a |
| protein binding | KLK15,BAI3,CTF1,TAP2,ANGPTL4,MCM10,NFIX,MRAP,GAD1,ITGAX |
Interacting Protein
GFPT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFPT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFPT2.
POT1;15-deoxy-delta(12,14
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References
- Verbovsek, U; Motaln, H; et al. Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma. PLOS ONE 9:-(2014).
- Kuo, CC; Lin, CY; et al. Frequent methylation of HOXA9 gene in tumor tissues and plasma samples from human hepatocellular carcinomas. CLINICAL CHEMISTRY AND LABORATORY MEDICINE 52:1235-1245(2014).
