GDI1
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Official Full Name
GDP dissociation inhibitor 1 -
Overview
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family,;small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between;cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound;rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked;nonspecific mental retardation. -
Synonyms
GDI1;GDP dissociation inhibitor 1;rab GDP dissociation inhibitor alpha;FLJ41411;GDI-1;GDIA_HUMAN;Guanosine diphosphate dissociation inhibitor 1;Mental retardation X-linked 41;Mental retardation X-linked 48;MRX41;MRX48;Oligophrenin 2;Oligophrenin-2;OPHN2;Protein XAP 4;Protein XAP-4;Protein XAP4;Rab GDI alpha;RABGD1A;RABGDIA;XAP 4;SMG p25A GDI
Recombinant Proteins
- Human
- Bovine
- Rat
- Zebrafish
- Cynomolgus
- Mouse
- E. coli
- Sf9 Insect Cell
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
- GST
Involved Pathway
GDI1 involved in several pathways and played different roles in them. We selected most pathways GDI1 participated on our site, such as Integrated Breast Cancer Pathway,Rho GTPase cycle,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling mediated by p38-alpha and p38-beta | USF1,KRT8,HBP1 |
| Rho GTPase cycle | STARD8,ARHGAP20,RHOJ,RHOT1,FAM13B1,ARHGAP8,FAM13A,FAM13B,RHOT2,ARHGEF18 |
| Signaling by Rho GTPases | FMNL2,ARHGAP26,CHN2,RHPN1,ARHGAP8,ARHGAP32,ARHGAP12,NOXO1A,TAGAPA,RHOT1 |
| Signal Transduction | WDR19,QRFP,GPR65,RXFP2B,DZIP1,RLN1,RGS11,ARHGEF18,APOM,ARHGAP12B |
| Integrated Breast Cancer Pathway | BACH1,EDAR,ALKBH1,USP16,DAG1,GRN,UBE2F,DCAKD,APOBEC3G,LGALS13 |
Protein Function
GDI1 has several biochemical functions, for example, GDP-dissociation inhibitor activity,GTPase activator activity,Rab GDP-dissociation inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDI1 itself. We selected most functions GDI1 had, and list some proteins which have the same functions with GDI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ARHGAP44,BCR,LLGL1,RIC8,WNT11,ARHGAP4A,RGS14A,ASAP1A,TBC1D26,ELMOD1 |
| protein binding | CD226,XAB2,INS,NPHS1,DNAI1,EIF4B,TPD52,INPP5D,IGF2R,COLQ |
| oxidoreductase activity | F8,APEX1,RYROXD1,DAO.3,HSD3B6,DHRS12,CYP8B1,FLJ13639,CBR1L,CYP4V8 |
| Rab GDP-dissociation inhibitor activity | GDI2 |
| GDP-dissociation inhibitor activity | GPSM1B,SH3BP4,RANBP1,GPSM1,ITGB1BP1,RGS14,GPSM2L,SH3BP4A |
| Rab GTPase binding | RAB3GAP2,RABGGTA,FER,ZFYVE20,MYO5A,AP1G1,TBC1D20,SYTL1,TMEM127,DENND5A |
Interacting Protein
GDI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDI1.
RAB4A;Rab10;RAB1A;LNX1;SPOP;HLA-B;YWHAZ;FBXO11;RAB24;FTSJ1;TK1;GNL1;dppA
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References
- Gallart-Palau, X; Serra, A; et al. Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia. NEUROCHEMISTRY INTERNATIONAL 80:87-98(2015).
- D'Adamo, P; Masetti, M; et al. RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 46:302-314(2014).
