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GDF1

  • Official Full Name

    growth differentiation factor 1

  • Overview

    This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of;proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein;containing seven conserved cysteine residues. The members of this family are regulators of cell growth and;differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the;establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This;protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene.

  • Synonyms

    GDF1;growth differentiation factor 1;embryonic growth/differentiation factor 1;GDF-1;DORV;DTGA3

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • Wheat Germ
  • In Vitro Cell Free System
  • Non
  • His
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GDF1-715H Active Recombinant Human GDF1 CHO Human Non 254-372 a.a.
GDF1-717H Active Recombinant Human Growth Differentiation Factor 1 CHO Human Non 254-372 a.a.
GDF1-045H Active Recombinant Human GDF1 Protein E.coli Human 254-372 a.a.
Gdf1-269M Recombinant Mouse Gdf1 Protein, His-tagged E.coli Mouse His Cys230~Arg357
Gdf1-270R Recombinant Rat Gdf1 Protein, His-tagged E.coli Rat His Leu183~Arg357
GDF1-4817H Recombinant Human GDF1 Protein, GST-tagged Wheat Germ Human GST
GDF1-5228HF Recombinant Full Length Human GDF1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 337 amino acids

    Involved Pathway

    GDF1 involved in several pathways and played different roles in them. We selected most pathways GDF1 participated on our site, such as Developmental Biology,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid metabolism NEU3.2,ARSA,GALCB,GAL3ST1A,GBA,CERS2A,UGCG,ARSF,OSBP,CERS1
    Developmental Biology NKX2.2A,CLTB,DPYSL3,DUSP6,PSPN,DRAP1,RHOB,DCX,INSM1B,CD24
    Sphingolipid de novo biosynthesis CERS3B,PPM1LA,CERS5,FA2H,VAPB,CERS4A,PPM1L,COL4A3BP,SPTLC1,OSBP
    Metabolism NDUFA11,PDK2B,SULT1B1,ABHD14B,MED19,PDPR,DUT,IVD,NUDT5,CKMT2A
    Metabolism of lipids and lipoproteins OSBP,NEU4,MED31,SACM1LB,ACOT9.1,MED16,PPM1LB,NFYBA,CYP2V1,ABHD3
    Signaling by NODAL PCSK6,LEFTY1,FOXH1,DRAP1,TDGF1,ACVR1C,CFC1

    Protein Function

    GDF1 has several biochemical functions, for example, cytokine activity,growth factor activity,transforming growth factor beta receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF1 itself. We selected most functions GDF1 had, and list some proteins which have the same functions with GDF1. You can find most of the proteins on our site.

    Function Related Protein
    transforming growth factor beta receptor binding BMP10,GDF10,BMP2B,MSTNB,GDF11,INHBAB,NODAL,GDF10B,TGFBRAP1,BMP3
    cytokine activity TNFSF9,Ccl27a,TNFSF12,OSTN,CD70,IFNL3,IFNA8,WNT5A,INHA,FAM3C
    growth factor activity FGF1A,INHBE,WISP3,FGF14,INHA,MSTNA,FGF18A,GDNF,VEGFC,FGF5

    Interacting Protein

    GDF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF1.

    Resources

    Gene Families

    What Is Tumor Necrosis Factor (TNF)/TNF Superfamily

    Research Area

    Early Endodermal Lineage Markers
    Early Mesodermal Lineage Markers
    Growth Differentiation Factor (GDF)
    Ectodermal Lineage Markers
    Endodermal Lineage Markers
    Mesodermal Lineage Markers

    References

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