GCHFR
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Official Full Name
GTP cyclohydrolase I feedback regulator -
Overview
GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. -
Synonyms
GCHFR;GTP cyclohydrolase I feedback regulator;GTP cyclohydrolase I feedback regulatory protein;GTP cyclohydrolase 1 feedback regulatory protein;GFRP;HsT16933;GFRP_HUMAN;MGC138467;MGC138469;p35;OTTHUMP00000160546
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Human
- Rat
- Chicken
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
GCHFR involved in several pathways and played different roles in them. We selected most pathways GCHFR participated on our site, such as Metabolism,Metabolism of nitric oxide,Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GCHFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | SPRB |
| eNOS activation and regulation | SPRB,NOSIP,CYGB1,CYGB2,LYPLA1,DDAH1,ZDHHC21,DDAH2,NOSTRIN,CYGB |
| Metabolism of nitric oxide | CYGB2,CYGB1,DDAH2,NOSIP,NOSTRIN,DDAH1,LYPLA1,SPRB,ZDHHC21,CYGB |
| Metabolism | CYP2K16,CA5B,AZIN2,CRAT,LYRM4,HAS3,PLIN2,ARL2,CYP2Y3,PIK3R6 |
Protein Function
GCHFR has several biochemical functions, for example, GTP cyclohydrolase binding,GTP-dependent protein binding,amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GCHFR itself. We selected most functions GCHFR had, and list some proteins which have the same functions with GCHFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme inhibitor activity | FRY,OAZ2B,UGT1A9,TAE1,NOTCH1,SLN,HSPBP1,APBA3,WFIKKN1,CSN2 |
| GTP-dependent protein binding | RAPGEF5,ARFIP2,RAB38,EEA1,CDC42,AP3B1,RAPGEF6,RAB32,PARD6A,RASGRP4 |
| amino acid binding | AGXT,TPH1,AARS2,ASS1,DDAH2,AARS,TDO2,DPYS,GOT2,TPH1A |
| protein binding | FAM207A,TNFRSF11A,Ctsl,VLDLR,COG1,SDCBP2,XPO1,TP63,FLG,RAD51C |
Interacting Protein
GCHFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GCHFR here. Most of them are supplied by our site. Hope this information will be useful for your research of GCHFR.
GCH1
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