GBP2
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Official Full Name
guanylate binding protein 2, interferon-inducible -
Overview
Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP. -
Synonyms
GBP2;guanylate binding protein 2, interferon-inducible;interferon-induced guanylate-binding protein 2;GBP 2;GTP binding protein 2;Guanine nucleotide binding protein 2;Guanylate binding protein 2 interferon inducible;HuGBP 2;HuGBP2;GBP-2;huGBP-2;GTP-binding protein 2;guanine nucleotide-binding protein 2
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Human Cell
- Mammalian cells
- E. coli
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His&T7
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
GBP2 involved in several pathways and played different roles in them. We selected most pathways GBP2 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with GBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | CD200R3,CFHL3,GRAP2B,MGC174152,TREML1,BLMH,ERAP1,IFI6,ABI1B,CYBB |
| Cytokine Signaling in Immune system | TRIM14,CSK,PEBP1,FRS2,DUSP5,LGALS9,IFITM2,ARIH1L,CRK,ADAR |
| Interferon Signaling | TRIM48,TRIM46,TRIM68,HERC5,TRIM22,IFIT10,OASL,TRIM14,XAF1,TRIM10 |
| Interferon gamma signaling | TRIM46,TRIM26,HLA-DQB2,TRIM22,IRF6,TRIM14,IRF4,TRIM45,GBP1,GBP4 |
| Interferon alpha/beta signaling | SAMHD1,IFI27,IRF2,IFIT2,IRF9,BST2,IFI35,XAF1,IFITM3,OASL |
Protein Function
GBP2 has several biochemical functions, for example, GTP binding,GTPase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GBP2 itself. We selected most functions GBP2 had, and list some proteins which have the same functions with GBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LGALSL,ARID5A,DDX21,CXorf48,ADAM15,CLK4,ZNRF1,HBA2,RAB7L1,CACNA2D1A |
| GTP binding | THG1L,RAB35,GIMAP1,RAB5AA,EEF1A1A,EEF2A.1,IRGC,GUCY1B3,RALAB,ARL8B |
| GTPase activity | RASEF,RAB38,TUBA1A,GNL1,TUBB4A,GIMAP7,RAB11BB,GNL2,EEF1A1,MXE |
Interacting Protein
GBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GBP2.
q9wmx2-pro_0000037548;BNIP3L;ANXA7;SAT1;GADD45A;GSK3B;SEPHS1;SERPINB9;FXR1;BID;HSPE1;CSNK2B;PPP1R8;STK3;MAPK8IP2;PAFAH1B3;RPS6KA1;btuC3;q81k32_bacan
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References
- James, SW; Banta, T; et al. Restraint of the G2/M Transition by the SR/RRM Family mRNA Shuttling Binding Protein SNXA(HRB1) in Aspergillus nidulans. GENETICS 198:617-U277(2014).
- Godoy, P; Cadenas, C; et al. Interferon-inducible guanylate binding protein (GBP2) is associated with better prognosis in breast cancer and indicates an efficient T cell response. BREAST CANCER 21:491-499(2014).
