GAN
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Official Full Name
gigaxonin -
Overview
This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008] -
Synonyms
GAN;gigaxonin;GAN1;KLHL16;kelch-like protein 16;kelch-like family member 16
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&T7
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GAN-13149H | Recombinant Human GAN, His-tagged | E.coli | Human | His | 248-597a.a. | |
| GAN-6202M | Recombinant Mouse GAN Protein | Mammalian Cell | Mouse | His |
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| GAN-287HCL | Recombinant Human GAN lysate | HEK293 | Human | Non |
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| GAN-1614H | Recombinant Human GAN protein, His & T7-tagged | E.coli | Human | His&T7 | Cys30~Gly326 |
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| GAN-3463M | Recombinant Mouse GAN Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| GAN-3463M-B | Recombinant Mouse GAN Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GAN-4717H | Recombinant Human GAN Protein, GST-tagged | Wheat Germ | Human | GST |
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| GAN-5376HF | Recombinant Full Length Human GAN Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 597 amino acids |
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Involved Pathway
GAN involved in several pathways and played different roles in them. We selected most pathways GAN participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing: Ubiquitination & | FBXO27,DZIP3,LRR1,ASB4,TRIM41,UBE2J2,KLHL21,LTN1,RBCK1,RNF19B |
| Class I MHC mediated antigen processing & | TRIM69,DZIP3,ASB8,TRIM9,TPP2,HUWE1,RNF41,SEC24A,TRIM63,RNF123 |
| Adaptive Immune System | BTLA,DCTN6,KLHL20,CD200R2,CD300LF,KIF11,KIF26A,RNF123,NRG3,CD200R4 |
| presentation | ASB8,NPEPPS,SEC61B,DTX3L,UFL1,ASB7,UBR2,TRIM9,RNF34,SH3RF1 |
| Proteasome degradation | MKRN1,UBE2J2,ASB7,VPRBP,UFL1,ASB6,LRR1,HECTD3,LRSAM1,RNF25 |
| Immune System | DEFB129,TRIM22,STUB1,GBP1,SEC61B,EDARADD,POLR3G,LRSAM1,RACGAP1,POLR3F |
Protein Function
GAN has several biochemical functions, for example, molecular_function,protein binding,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GAN itself. We selected most functions GAN had, and list some proteins which have the same functions with GAN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin-protein transferase activity | KBTBD12,KLHDC8A,KLHL15,KLHL26,RNF40,KLHL1,KLHL4,KLHL40A,BACH1,CUL3 |
| molecular_function | LRBA,TMEM246,TIMM21,TSPAN3,TM7SF3,ECRG4A,GM14632,KRBA1,EMILIN3,BNIP4 |
| protein binding | EBF1,RPRD1A,ZNF286A,MAGEA3,HLX,YIF1A,CDCA5,ZFP932,FIGNL1,DUSP5 |
Interacting Protein
GAN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAN here. Most of them are supplied by our site. Hope this information will be useful for your research of GAN.
UBA1;MAP1B;TBCB;b4dyc6_human;HSP90AB1;SFN;ATG16L1;NUDCD3;ATG16L1
Resources
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References
- Wen, PY; Li, DY; et al. Identification of Degradation Mechanisms Based on Thermal Characteristics of InGaN/GaN Laser Diodes. IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS 21:-(2015).
- Hwang, HY; Choi, SB; et al. Combined Effect of Carrier Localization and Polarity in InxGa1-xN/GaN Quantum Wells. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5933-5936(2015).
