GAD1
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Official Full Name
glutamate decarboxylase 1 (brain, 67kDa) -
Overview
Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L-glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD67 is a cytoplasmic protein and is encodes on chromosome 2. -
Synonyms
GAD1;glutamate decarboxylase 1 (brain, 67kDa);GAD, glutamate decarboxylase 1 (brain, 67kD);glutamate decarboxylase 1;GAD-67;67 kDa glutamic acid decarboxylase;glutamate decarboxylase 67 kDa isoform;GAD;SCP;CPSQ1;FLJ45882
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- Insect Cell
- HEK293 cells
- In Vitro Cell Free System
- HEK293T
- HEK293
- Mammalian cells
- His
- Non
- His&S
- His&GST
- Myc&DDK
- His&Fc&Avi
- GST
- Flag
Involved Pathway
GAD1 involved in several pathways and played different roles in them. We selected most pathways GAD1 participated on our site, such as Alanine, aspartate and glutamate metabolism,beta-Alanine metabolism,Taurine and hypotaurine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type I diabetes mellitus | PRF1,INS1,FAS,INS,GZMB,HLA-DRB4,IL1A,IL12B,HLA-F,HLA-DQB1 |
| Metabolic pathways | UQCRC2,ASAH2,LDHAL6B,CYP26B1,CMAS,NT5C1B,HSD17B12A,ATP5I,FASN,ASPA |
| GABAergic synapse | GNB3,PRKACB,GABRA6,GNG2,PRKACA,GNGT1,PLCL1,GNAO1,SLC12A5,GNG5 |
| Alanine, aspartate and glutamate metabolism | GLS,ALDH4A1,ADSL,GPT2,ASL2,GAD1B,CPS1,GLUD1B,AGXT,GPT |
| Taurine and hypotaurine metabolism | GAD2,ADOB,BAAT,CDO1,ADO,GGT1,CSAD,GAD1B,GGT1A,GGT5A |
| Butanoate metabolism | ACSM1,BDH2,ACAT2,DHRS13L1,OXCT1,HADH,HADHAA,ACSM2B,EHHADH,ACSM3 |
| beta-Alanine metabolism | ALDH1B1,HADHA,MLYCD,HADHAA,ALDH9A1B,AOC2,SRM,CARNS1,ALDH2,ALDH6A1 |
Protein Function
GAD1 has several biochemical functions, for example, glutamate decarboxylase activity,protein binding,pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAD1 itself. We selected most functions GAD1 had, and list some proteins which have the same functions with GAD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MRPL1,PELI2,Trl,MED20,ZBED3,FBXO33,AREG,KLF17,GFM1,GATA5 |
| pyridoxal phosphate binding | GCAT,CTHL,KYNU,PYGM,GPT2,AGXT2L1,MOSC2,ABAT,CCBL1,SHMT2 |
| glutamate decarboxylase activity | GAD1B,GLUL,GAD2 |
Interacting Protein
GAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAD1.
HAAO;CMTM5;STK3;AGTRAP;ABL1;JUN;FYN;NCK1;GRB2
Resources
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References
- Zhubi, A; Chen, Y; et al. Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. TRANSLATIONAL PSYCHIATRY 4:-(2014).
- Jaraj, SJ; Augsten, M; et al. GAD1 is a biomarker for benign and malignant prostatic tissue. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 45:39-45(2011).
