Fig4
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Official Full Name
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
- GST
Involved Pathway
Fig4 involved in several pathways and played different roles in them. We selected most pathways Fig4 participated on our site, such as 3-phosphoinositide biosynthesis,Metabolism,Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fig4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PI Metabolism | TPTE,SACM1LB,SACM1L,ARF3,PITPNB,SACM1LA |
| Phospholipid metabolism | ARF3,CEPT1A,CPNE7,SACM1LA,SACM1LB,PLBD1,TPTE,AWAT2,PLD6,ABHD3 |
| Metabolism | MED21,Agmo,CYP4F12,KCNS3A,NAMPT,KCNC2,HIBADH,AKR1C6,EPM2A,CYP2K19 |
| Synthesis of PIPs at the Golgi membrane | SACM1LA,ARF3,SACM1LB,SACM1L,TPTE |
| Metabolism of lipids and lipoproteins | ABHD3,STARD5,ACOT7,MED15,CERS5,APOEA,LMF2,SLCO1B1,CEPT1,MED31 |
| 3-phosphoinositide biosynthesis | CDIPT,PIP5KL1,PIK3R6 |
Protein Function
Fig4 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity,phosphatidylinositol-3-phosphatase activity,phosphatidylinositol-4-phosphate phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fig4 itself. We selected most functions Fig4 had, and list some proteins which have the same functions with Fig4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol-3-phosphatase activity | MTMR2,MTMR8,MTMR1,MTMR1A,MTM1,MTMR14,SACM1L,MTMR1B,PTEN,MTMR3 |
| phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity | CTDSPL2A,CTDSPL2B,PXYLP1,SACM1LA,SACM1L,TENC1,PTPRQ,NT5DC3,PIKFYVE,SGPP2 |
| protein binding | FAM72A,ORMDL3,RPS6KC1,EPB41L1,ARF4,POLE4,FUNDC1,TAF13,TRIM63,WIPF2 |
| phosphatidylinositol-4-phosphate phosphatase activity | PTPRQ,SACM1LA,CTDSPL2A,TENC1,NT5DC3,SACM1LB,PXYLP1,CTDSPL2B,SACM1L,SGPP2 |
Interacting Protein
Fig4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fig4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fig4.
VAC14;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
Resources
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References
- Vaccari, I; Carbone, A; et al. Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy. HUMAN MOLECULAR GENETICS 24:383-396(2015).
- Liu, ZJ; Li, HF; et al. Identify mutation in amyotrophic lateral sclerosis cases using HaloPlex target enrichment system. NEUROBIOLOGY OF AGING 35:-(2014).
