FUT2
-
Official Full Name
fucosyltransferase 2 (secretor status included) -
Overview
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
FUT2;fucosyltransferase 2 (secretor status included);SE;galactoside 2-alpha-L-fucosyltransferase 2;alpha (1;2) fucosyltransferase;alpha(1;2)FT2;galactoside 2 alpha L fucosyltransferase 2;GDP L fucose:beta D galactoside 2 alpha L fucosyltransferase 2;Se2;SEC2;secretor blood group alpha 2 fucosyltransferase;secretor factor;sej;Fucosyltransferase 2;alpha(1,2)FT2;alpha(1,2)FT 2;OTTHUMP00000226681;OTTHUMP00000226682;alpha (1,2) fucosyltransferase;secretor blood group alpha-2-fucosyltransferase;GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosylt;B12QTL1
Recombinant Proteins
- Human
- Rat
- Gorilla gorilla gorilla (Western lowland gorilla)
- Pan troglodytes
- Pongo Pygmaeus
- HEK293
- Mammalian Cell
- E.coli
- Wheat Germ
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- His&Fc&Avi
- His&GFP
- GST
Involved Pathway
FUT2 involved in several pathways and played different roles in them. We selected most pathways FUT2 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series,Glycosphingolipid biosynthesis - globo series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - lacto and neolacto series | FUT3,B4GALT2,B3GNT3,B4GALT4,GGTA1,B3GNTL2,FUT5,B3GNT5B,ST3GAL3,B3GNT4 |
| Metabolic pathways | PIGF,CTH,SC4MOL,KMO,PI4KA,TDO2A,NDUFV1,PGM1,C1GALT1,DHRS9 |
| Glycosphingolipid biosynthesis - globo series | ST3GAL2,FUT9,NAGA,FUT1,GBGT1L4,GBGT1,GLA,ST8SIA1,FUT9A,ST3GAL1 |
Protein Function
FUT2 has several biochemical functions, for example, fucosyltransferase activity,galactoside 2-alpha-L-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT2 itself. We selected most functions FUT2 had, and list some proteins which have the same functions with FUT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| galactoside 2-alpha-L-fucosyltransferase activity | FUT1 |
| fucosyltransferase activity | FUT6,FUT9D,GALNTL4,POFUT1,FUT9,FUT9B,FUT1,PIGB,DPY19L4,POMGNT2 |
Interacting Protein
FUT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FUT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FUT2.
ZDHHC17
Resources
Related Services
Related Products
References
- Friedrich, M; Diegelmann, J; et al. IL-17A Alone Weakly Affects the Transcriptome of Intestinal Epithelial Cells but Strongly Modulates the TNF-alpha-induced Expression of Inflammatory Mediators and Inflammatory Bowel Disease Susceptibility Genes. INFLAMMATORY BOWEL DISEASES 20:1502-1515(2014).
- Khodayar-Pardo, P; Martinez-Costa, C; et al. Norovirus GII.4 Antibodies in Breast Milk and Serum Samples Their Role Preventing Virus-Like Particles Binding to Their Receptors. PEDIATRIC INFECTIOUS DISEASE JOURNAL 33:554-559(2014).
