FRZB
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Official Full Name
myozenin 3 -
Overview
Sclerostin is a protein that in humans is encoded by the SOST gene. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced by the osteocyte and has anti-anabolic effects on bone formation. -
Synonyms
FRZB;myozenin 3;CS-3;CS3;FRP3;FATZ-related protein 3;calsarcin-3;myozenin-3
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FRZB-001H | Recombinant Full Length Human FRZB protein, His tagged | HEK293 | Human | His | Full L. 33-325 aa |
|
| FRZB-3270H | Recombinant Human FRZB protein(Ala32-Asn325), His-tagged | HEK293 | Human | His | Ala32-Asn325 |
|
Involved Pathway
FRZB involved in several pathways and played different roles in them. We selected most pathways FRZB participated on our site, such as Adipogenesis,Endochondral Ossification, which may be useful for your reference. Also, other proteins which involved in the same pathway with FRZB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endochondral Ossification | SOX6,CST5,COL2A1,CDKN1C,MMP13,ADAMTS5,SOX9A,COL10A1A,KIF3A,MGP |
| Adipogenesis | KLF6,CFD,DVL1,HMGA1,NCOA2,MEF2AA,AGT,NR1H3,KLF6A,CISD1 |
Protein Function
FRZB has several biochemical functions, for example, NOT G-protein coupled receptor activity,NOT Wnt-activated receptor activity,Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FRZB itself. We selected most functions FRZB had, and list some proteins which have the same functions with FRZB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Wnt-protein binding | LRP6,FZD7,PORCN,ROR2,APCDD1,FZD6,SFRP2,LRP5L,FZD3,ROR1 |
| NOT Wnt-activated receptor activity | SFRP2,SMO,SFRP1B,SZL,TSPAN12,SFRP4,SFRP1,SFRP1A,SETD6 |
| NOT G-protein coupled receptor activity | SFRP2,SFRP1A,SFRP1,SFRP4,SZL,LGR4,SFRP1B,LGR5,LGR6 |
Interacting Protein
FRZB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FRZB here. Most of them are supplied by our site. Hope this information will be useful for your research of FRZB.
RBX1;POLA2;SMAD1;metE;BBS10;PNO1;EHF;ELF5
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References
- Chu, QQ; Cai, LY; et al. Dkk2/Frzb in the dermal papillae regulates feather regeneration. DEVELOPMENTAL BIOLOGY 387:167-178(2014).
- Churchman, SM; Ponchel, F; et al. Transcriptional profile of native CD271+ multipotential stromal cells: Evidence for multiple fates, with prominent osteogenic and wnt pathway signaling activity. ARTHRITIS AND RHEUMATISM 64:2632-2643(2012).
