FPGT
-
Official Full Name
fucose-1-phosphate guanylyltransferase -
Overview
L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. -
Synonyms
FPGT;fucose-1-phosphate guanylyltransferase;GFPP;Fucose 1 phosphate guanyltransferase;Fucose 1 phosphate guanylyltransferase;GDP beta L fucose pyrophosphorylase;GDP L fucose diphosphorylase;GDP L fucose pyrophosphorylase;GDP-L-fucose diphosphorylase;GDP-beta-L-fucose pyrophosphorylase;fucose-1-phosphate guanyltransferase
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Chicken
- Human
- Mouse
- Mammalian Cell
- HEK293
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FPGT-1749R | Recombinant Rhesus monkey FPGT Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
|
|
| FPGT-2894Z | Recombinant Zebrafish FPGT | Mammalian Cell | Zebrafish | His |
|
|
| FPGT-4501C | Recombinant Chicken FPGT | Mammalian Cell | Chicken | His |
|
|
| FPGT-6139HCL | Recombinant Human FPGT 293 Cell Lysate | HEK293 | Human | Non |
|
|
| FPGT-1396H | Recombinant Human FPGT Protein (1-594 aa), His-tagged | Yeast | Human | His | 1-594 aa |
|
| FPGT-1571R | Recombinant Rhesus Macaque FPGT Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
|
|
| FPGT-1571R-B | Recombinant Rhesus Macaque FPGT Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
||
| FPGT-4484H | Recombinant Human FPGT Protein, GST-tagged | Wheat Germ | Human | GST |
|
|
| FPGT-5129HF | Recombinant Full Length Human FPGT Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 594 amino acids |
|
| FPGT-740H | Recombinant Human FPGT Protein, His-tagged | E.coli | Human | His | Leu127~Ser377 |
|
| Fpgt-741M | Recombinant Mouse Fpgt Protein, His-tagged | E.coli | Mouse | His | His314~Leu513 |
|
Involved Pathway
FPGT involved in several pathways and played different roles in them. We selected most pathways FPGT participated on our site, such as Fructose and mannose metabolism,Amino sugar and nucleotide sugar metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FPGT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GCDH,AGK,ACLYA,PRIM1,NAGLU,HDC,GGT7,PLD3,PIGC,PKM2 |
| Amino sugar and nucleotide sugar metabolism | GALE,GPI,HK1,UGP2,NAGK,GFPT2,GMPPAA,PMM1,CHIA.3,CHIT1 |
| Fructose and mannose metabolism | GMPPAA,GMDS,PFKL,HK1,AKR1B8,TIGARB,AKR1B7,TPI1A,TSTA3,PFKFB2A |
Protein Function
FPGT has several biochemical functions, for example, GTP binding,catalytic activity,fucose-1-phosphate guanylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FPGT itself. We selected most functions FPGT had, and list some proteins which have the same functions with FPGT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| catalytic activity | TM9SF1,PPM1AB,CKMT2A,SLC3A2A,IMPDH1B,HSD17B1,GOT2B,PPM1LB,GMPR2,ECHDC3 |
| GTP binding | RAB7A,RAB27A,RAC1,DNM1L,RABL2A,RHEB,RAB5B,LRRK2,RHOAC,CDC42 |
Interacting Protein
FPGT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FPGT here. Most of them are supplied by our site. Hope this information will be useful for your research of FPGT.
Resources
Related Services
Related Products
References
- Bochicchio, MA; Vaira, L; et al. FPGT: An Online System for Customized Fetal and Pediatric Growth Tracking. 2014 IEEE-EMBS INTERNATIONAL CONFERENCE ON BIOMEDICAL AND HEALTH INFORMATICS (BHI) :424-427(2014).
- Trifonov, VA; Dementyeva, PV; et al. Transcription of a protein-coding gene on B chromosomes of the Siberian roe deer (Capreolus pygargus). BMC BIOLOGY 11:-(2013).
