FOXO3
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Official Full Name
forkhead box O3 -
Overview
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] -
Synonyms
FOXO3;forkhead box O3;FOXO2;AF6q21;FKHRL1;FOXO3A;FKHRL1P2;forkhead box protein O3;forkhead box O3A;forkhead in rhabdomyosarcoma-like 1;forkhead homolog (rhabdomyosarcoma) like 1;forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- HEK293
- Mammalian Cell
- E.coli
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- Mamanlian cells
- Non
- Myc&DDK
- His
- His&T7
- Flag
- His&SUMO
- His&Fc&Avi
- GST
Involved Pathway
FOXO3 involved in several pathways and played different roles in them. We selected most pathways FOXO3 participated on our site, such as Chemokine signaling pathway,FoxO signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-small cell lung cancer | PIK3R1,RB1,MAPK1,ARAF,PIK3CA,PIK3R3,RARB,MAP2K1,TP53,NRAS |
| FoxO signaling pathway | GADD45G,HOMER1,PRKAB1,RAF1A,ATM,CDKN2B,FOXG1A,G6PCA.1,SIRT1,MAPK11 |
| Chemokine signaling pathway | CCL28,GM2506,CXCL8,CCL6,PLCB2,GNAI1,XCR1,CXCR6,GNGT1,ITK |
| PIK-Akt signaling pathway | THBS3,MAP2K2,LAMA5,GHR,ITGA5,LAMC1,PIK3R5,TCL1B,FGF5,G6PC3 |
| Prolactin signaling pathway | INS1,TH,SHC2,STAT1,PIK3R3,NEK3,SRC,MAPK8,PRL,SOS1 |
| AMPK signaling pathway | PFKFB3,MAP3K7,SCD5,RPS6KB1,G6PC2,INSR,CRTC2,PPP2R3C,PRKAG2,G6PC3 |
| Endometrial cancer | APC2,KRAS,TP53,TRP53,AXIN2,MLH1,MAP2K2,ILK,SOS1,TCF7 |
| Neurotrophin signaling pathway | GRB2,MAPK12,RAC1,MAPK8,MAP2K5,CALML3,NFKBIA,AKT1,IRAK4,SH2B1 |
Protein Function
FOXO3 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXO3 itself. We selected most functions FOXO3 had, and list some proteins which have the same functions with FOXO3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | BCL11AA,FOXI3B,HIVEP2A,LHX2B,FOXC1B,HOXA11,FOXQ1B,POU3F3B,SPI1B,MEOX1 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | BHLHA15,FOXF2,HIF1A,GRHL3,MYOCD,GATA6,GATA2,MAFG,ATF1,PPARG |
| transcription factor activity, sequence-specific DNA binding | NFE2L1,NPAS2,DMRTC2,ZNF37A,CBFB,ALX3,ESRRGB,PRDM1A,TEF,MNX2A |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | HIF1AL2,PEG3,SOX5,RUNX2,FOXA2,ELF2,MAZ,EPAS1B,TFDP1A,TAL2 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | VAX1,ETV6,MITF,KLF6A,CGGBP1,BCL6,ESX1,HOXD9,CDX2,ARID5B |
| DNA binding | SIX3B,CERS4,HIST1H2AB,ZNF436,EHF,ZNF136,IRX3A,TFCP2,BANF2,CHD8 |
| transcription cofactor binding | CHD6,TRP53,KLF4 |
| protein binding | CHN1,SCO2,TTC6,ABCG2,TNPO2,EPRS,SLC5A1,SCRN1,PLEKHF1,RPA3 |
| chromatin DNA binding | ZIC2,VAX2,SRF,BCL6,HIST1H1E,PRDM14,MED1,GATA1,THRA,AASS |
Interacting Protein
FOXO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXO3.
SIRT1;TP53;SMAD4;YWHAB;YWHAH;YWHAZ;PPP2R1A
FOXO3 Related Signal Pathway
Resources
Research Area
Apoptosis Transcription Factors and RegulatorsTranscription Regulators in VSMC
G1 (Restriction) Checkpoints
Related Services
Related Products
References
- Haas, MJ; Onstead-Haas, L; et al. The Effect of Black Seed (Nigella sativa) Extract on FOXO3 Expression in HepG2 Cells. PHYTOTHERAPY RESEARCH 28:873-879(2014).
- Tikhanovich, I; Kuravi, S; et al. Regulation of FOXO3 by Phosphorylation and Methylation in Hepatitis C Virus Infection and Alcohol Exposure. HEPATOLOGY 59:58-70(2014).
