FOXL2
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Official Full Name
forkhead box L2 -
Overview
Forkhead box protein L2 (FOXL2) may function as a transcriptional regulator. FOXL2 is?expressed in the nucleus of somatic cells of the developing gonad and and in the follicular cells of the adult ovary. FOXL2 is also expressed in the developing eyelid. -
Synonyms
FOXL2;forkhead box L2;BPES;forkhead box protein L2;BPES1;forkhead transcription factor FOXL2;PFRK;POF3;PINTO
Recombinant Proteins
- Chicken
- Zebrafish
- Mouse
- Human
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- HEK293F
- His
- Myc&DDK
- His&GST
- His&Fc&Avi
- GST
- N-His&C-Myc
Involved Pathway
FOXL2 involved in several pathways and played different roles in them. We selected most pathways FOXL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
FOXL2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,cysteine-type endopeptidase regulator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXL2 itself. We selected most functions FOXL2 had, and list some proteins which have the same functions with FOXL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | REST,HOXB2A,ELF3,TGIF2,FOXO6,HOXB6A,DMRTA2,RORA,POU4F2,ZNF643 |
| DNA binding | GTF2IRD2,BANP,GTF2F2A,PSMC3IP,HNRNPU,EP400,MYEF2,ZNF556,ISL1L,EPAS1 |
| protein binding | FANCG,PODXL2,ZMAT3,SALL1,EIF4EBP1,AP2A2,C2orf65,BTBD1,NIPAL1,RANBP3 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | NOBOX,MEF2C,CREB3L2,CEBPB,AKNA,ETV1,GLI2,HOXD13,SIX1,TFAP4 |
| ubiquitin conjugating enzyme binding | RNF180,GRIK2,DCUN1D2A,ARIH2,DCUN1D2B,RNF144AA,RNF19A,RNF14,TCHP,ARIH1 |
| sequence-specific DNA binding | FOXB1A,ETV5B,NLRP3,FOXS1,HOXC6A,LMX1B,TP53,CHES1,FOXP3A,HOXA7 |
| estrogen receptor binding | PPARGC1A,NRIP1,WIPI1,HSD17B10,MED1,XBP1,FUS,NKX3-1,MMS19,DDX17 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ATF7,NFATC3,MAFB,RBPJA,SMAD2,IRF4,SALL1,NKX6-1,SMAD3,PATZ1 |
Interacting Protein
FOXL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXL2.
Esr2;Esr1;sox9_mouse_gene
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References
- Devouassoux-Shisheboran, M; et al. Ovarian cancer: molecular biology. ONCOLOGIE 16:306-312(2014).
- Stewart, CJR; Alexiadis, M; et al. An immunohistochemical and molecular analysis of problematic and unclassified ovarian sex cord stromal tumors. HUMAN PATHOLOGY 44:2774-2781(2013).
