FOXC2
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Official Full Name
forkhead box C2 (MFH-1, mesenchyme forkhead 1) -
Overview
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008] -
Synonyms
FOXC2;forkhead box C2 (MFH-1, mesenchyme forkhead 1);LD;MFH1;MFH-1;FKHL14;forkhead box protein C2;MFH-1,mesenchyme forkhead 1;transcription factor FKH-14;mesenchyme fork head protein 1;forkhead-related protein FKHL14;forkhead, Drosophila, homolog-like 14
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- HEK293
- E.coli
- Mammalian Cell
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Non
- Myc&DDK
- His
- GST
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FOXC2-28108TH | Recombinant Human FOXC2 | Wheat Germ | Human | Non | 81 amino acids |
|
| FOXC2-6160H | Recombinant Human FOXC2 protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| FOXC2-6161H | Recombinant Human FOXC2 protein, His-tagged | E.coli | Human | His | full length |
|
| FOXC2-6695C | Recombinant Chicken FOXC2 | Mammalian Cell | Chicken | His |
|
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| FOXC2-6160HCL | Recombinant Human FOXC2 293 Cell Lysate | HEK293 | Human | Non |
|
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| Foxc2-3071M | Recombinant Mouse Foxc2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
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| FOXC2-3485H | Recombinant Human FOXC2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
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| FOXC2-4438H | Recombinant Human FOXC2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| FOXC2-5051HF | Recombinant Full Length Human FOXC2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 501 amino acids |
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| FOXC2-5898HFL | Recombinant Full Length Human FOXC2 protein, Flag-tagged | Mamanlian cells | Human | Flag | Full L. |
|
Involved Pathway
FOXC2 involved in several pathways and played different roles in them. We selected most pathways FOXC2 participated on our site, such as Adipogenesis,Heart Development, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOXC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Heart Development | FOXH1,TBX20,TBX5,SMYD1,GATA6,FOXC1,BMP10,NKX2,HEY1,IRX4 |
| Adipogenesis | GATA2,SMAD3B,HMGA1-RS1,GTF3AA,NDN,DVL1,MEF2AA,DDIT3,KLF7,GATA2A |
Protein Function
FOXC2 has several biochemical functions, for example, chromatin DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FOXC2 itself. We selected most functions FOXC2 had, and list some proteins which have the same functions with FOXC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | ZBTB14,HHEX,CREBL2,FOXC1,NR5A5,EVE1,POU5F3,POU3F2A,TCF7L2,PAX7A |
| chromatin DNA binding | SRF,WBP2,RUVBL2,SMAD3,RARA,GRHL2,INSM1A,H1F0,THRA,RXRA |
| protein binding | CAMK2D,EPC1,MEX3C,PARK2,CCDC55,LMLN,ZBTB5,SLC30A8,PRPF8,SMARCA2 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | POU1F1,RFX4,RAX,MEF2C,PGR,NR2E1,GATA2,PHOX2B,SIX2,SREBF1 |
| transcription factor activity, sequence-specific DNA binding | ZNF71,ZNF445,CEBP1,FOXG1C,UBP1,POU2F1,ZNF256,THRB,GRHL2,ZFP39 |
| transcription regulatory region DNA binding | TNF,NFKB1,RFX3,PHB,TCF7L2,REST,ZFP161,PROX1,FOXA3,IKZF2 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | HNF4A,MYF5,MYOD1,BHLHE40,FOXC1,GATA6,PTH,SNAI2,FOXF2A,ZFHX3 |
Interacting Protein
FOXC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOXC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOXC2.
TRIM27;PPP2R2A;TAX1BP1;RBPMS;q96iq6_human;PIN1;MYC;PPP2R1A
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References
- Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).
- Bai, XM; Wang, J; et al. Prostaglandin E-2 stimulates beta 1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-kappa B pathway. SCIENTIFIC REPORTS 4:-(2014).
