FOLR2
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Official Full Name
folate receptor 2 (fetal) -
Overview
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
FOLR2;folate receptor 2 (fetal);FBP;FR-P3;FR-BETA;BETA-HFR;FBP/PL-1;folate receptor beta;folate receptor, beta;folate receptor, fetal/placental;placental folate-binding protein;folate-binding protein, fetal/placental
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- Mouse
- HEK293
- Mammalian Cell
- Wheat Germ
- Human Cell
- E.coli
- Insect Cell
- In Vitro Cell Free System
- His
- Non
- His&Avi
- His&Fc&Avi
- GST
Involved Pathway
FOLR2 involved in several pathways and played different roles in them. We selected most pathways FOLR2 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with FOLR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | FGFR2,SMAP1,VPS37D,MVB12BB,IL2RGB,MDM2,GRK7B,CYTH2,TGFB1,EHD2B |
Protein Function
FOLR2 has several biochemical functions, for example, drug binding,folic acid binding,folic acid receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FOLR2 itself. We selected most functions FOLR2 had, and list some proteins which have the same functions with FOLR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug binding | ATP5O,PDE10A,GSTP2,ADRB2,P2RX2,TLR7,PPP3CA,FABP1,PPARD,HTR2C |
| methotrexate binding | DAAM2,DHFR,FOLR1 |
| folic acid transporter activity | SLC46A1,SLC25A32,SLC19A2,DAAM2,SLC19A1,FOLR1 |
| folic acid binding | DHFR,SLC46A1,MTHFS,DMGDH,DAAM2,FOLR1,SLC19A1,FTCD,FOLR3,GNMT |
| folic acid receptor activity | DAAM2 |
Interacting Protein
FOLR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FOLR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FOLR2.
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