FMO4
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Official Full Name
flavin containing monooxygenase 4 -
Overview
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region.Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. -
Synonyms
FMO4;flavin containing monooxygenase 4;FMO2;dimethylaniline monooxygenase [N-oxide-forming] 4;Dimethylaniline monooxygenase [N oxide forming] 4;Dimethylaniline monooxygenase 4;Dimethylaniline oxidase 4;FMO 2;FMO 4;FMO4_HUMAN;Hepatic flavin containing monooxygenase 4;Hepatic flavin-containing monooxygenase 4;OTTHUMP00000060454
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
FMO4 involved in several pathways and played different roles in them. We selected most pathways FMO4 participated on our site, such as Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with FMO4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - cytochrome P | UGT1AB,UGT1A6A,GSTM4,FMO2,FMO3,UGT2A1,GSTA4,UGT1A6B,GSTAL,GSTP2 |
Protein Function
FMO4 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FMO4 itself. We selected most functions FMO4 had, and list some proteins which have the same functions with FMO4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LRRIQ3,RABAC1,FAM110C,MAPT,CDKN3,IQCB1,ITM2B,SYNE1,INTS10,RBPJ |
Interacting Protein
FMO4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FMO4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FMO4.
Resources
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References
- Veeravalli, S; Omar, BA; et al. The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance. BIOCHEMICAL PHARMACOLOGY 90:88-95(2014).
- Uno, Y; Shimizu, M; et al. Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque. BIOCHEMICAL PHARMACOLOGY 85:1837-1847(2013).
