FLII
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Official Full Name
flightless I homolog -
Overview
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. -
Synonyms
FLII;flightless I homolog (Drosophila);flightless I (Drosophila) homolog;protein flightless-1 homolog;FLI;Fli1;FLIL;MGC39265
Recombinant Proteins
- Bacillus subtilis
- Chicken
- Mouse
- Zebrafish
- Human
- E. coli or Yeast
- Mammalian Cell
- Yeast
- E.coli
- HEK293
- His
- His&T7
- His&B2M
- His&Fc&Avi
- His&Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FLII-1163B | Recombinant Bacillus subtilis FLII protein, His-tagged | E. coli or Yeast | Bacillus subtilis | His |
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| FLII-2342C | Recombinant Chicken FLII | Mammalian Cell | Chicken | His |
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| FLII-5920M | Recombinant Mouse FLII Protein | Mammalian Cell | Mouse | His |
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| FLII-8204Z | Recombinant Zebrafish FLII | Mammalian Cell | Zebrafish | His |
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| FLII-1722M | Recombinant Mouse FLII Protein (495-827 aa), His-tagged | Yeast | Mouse | His | 495-827 aa |
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| FLII-1738H | Recombinant Human FLII protein, His & T7-tagged | E.coli | Human | His&T7 | Leu896~Phe1176 |
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| FLII-2243M | Recombinant Mouse FLII Protein (495-827 aa), His-B2M-tagged | E.coli | Mouse | His&B2M | 495-827 aa |
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| FLII-2953H | Recombinant Human FLII Protein (Leu896-Phe1176), N-His tagged | E.coli | Human | His | Leu896-Phe1176 |
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| FLII-3278M | Recombinant Mouse FLII Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FLII-3278M-B | Recombinant Mouse FLII Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FLII-7644H | Recombinant Human FLII protein, His&Myc-tagged | E.coli | Human | His&Myc | 495-827a.a. |
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Involved Pathway
FLII involved in several pathways and played different roles in them. We selected most pathways FLII participated on our site, such as XPodNet - protein-protein interactions in the podocyte expanded by STRING, which may be useful for your reference. Also, other proteins which involved in the same pathway with FLII were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| XPodNet - protein-protein interactions in the podocyte expanded by STRING | GMCL1,O3far1,CHD1L,CMIP,ARHGAP32,FAM65A,OASL2,SMARCD3,RAVER1,SNTB1 |
Protein Function
FLII has several biochemical functions, for example, actin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FLII itself. We selected most functions FLII had, and list some proteins which have the same functions with FLII. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HIST1H4B,MALT1,GLI1,MT1X,PRMT2,PLEKHB2,HNRNPH3,DNM1L,NEDD9,SRGAP1 |
| actin binding | TNNT2A,EPS8L1,SYN1,MSRB1A,DIAP3,UPF3B,MYHC4,ANTXR2A,CALD1B,PHACTR3B |
Interacting Protein
FLII has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FLII here. Most of them are supplied by our site. Hope this information will be useful for your research of FLII.
Camk2d;Camk2b;Ywhae;Ywhaz;Pgls
Resources
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References
- Ruzehaji, N; Kopecki, Z; et al. Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes. DIABETOLOGIA 57:402-412(2014).
- Kopecki, Z; Ruzehaji, N; et al. Topically Applied Flightless I Neutralizing Antibodies Improve Healing of Blistered Skin in a Murine Model of Epidermolysis Bullosa Acquisita. JOURNAL OF INVESTIGATIVE DERMATOLOGY 133:1008-1016(2013).
