FHL2
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Official Full Name
four and a half LIM domains 2 -
Overview
Proteins containing LIM domains (which are double zinc finger motifs implicated in protein binding) are important regulators of cell growth, cell differentiation, and remodeling of the cell cytoskeleton. Human Four-and-a-half LIM-only protein 2 (FHL2), al -
Synonyms
FHL2;four and a half LIM domains 2;four and a half LIM domains protein 2;DRAL;SLIM3;LIM domain protein DRAL;aging-associated gene 11;skeletal muscle LIM-protein 3;four and a half LIM-domain protein 2;down-regulated in rhabdomyosarcoma LIM protein
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
FHL2 involved in several pathways and played different roles in them. We selected most pathways FHL2 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FHL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | OSCAR,MAP3K14,PLCG2,TAB2,MAPK11,TNF,TYROBP,SFPI1,FOSL2,LILRA3 |
Protein Function
FHL2 has several biochemical functions, for example, androgen receptor binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FHL2 itself. We selected most functions FHL2 had, and list some proteins which have the same functions with FHL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | SQSTM1,STAT6,SHMT2,APOA1,HSP90AA1,CLDN2,RASSF3,HCFC1,GRIN3A,PITX2 |
| androgen receptor binding | CTNNB1,RNF14,PARK7,NCOA1,RNF6,EP300,FOXP1,GRIP1,PRPF6,TCF21 |
| transcription coactivator activity | RAN,HIF3A,ECD,HTATIP2,CREBBP,PRRX1,EDF1,NFKB2,MED23,MTA1 |
| zinc ion binding | TRIM5,DIDO1,CHD4,HE2,ZFYVE1,BHMT2,APOBEC2B,TRIM109,NR2E3,PCGF6 |
| protein binding | CYFIP1,HSPA4,GCKR,SHROOM2,LIMD2,STX1A,CCDC25,COX17,NRXN1,PLK4 |
| transcription factor binding | GCM1,DOT1L,KDM1A,AHR,APBB1,MECP2,TAF12,ZBTB49,TCF12,TRAPPC2 |
Interacting Protein
FHL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FHL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FHL2.
BRCA1;RFX3;GNG12;FOXO1
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References
- Verset, L; Tommelein, J; et al. Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer. BRITISH JOURNAL OF CANCER 109:114-120(2013).
- Huss, S; Stellmacher, C; et al. Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. BMC GASTROENTEROLOGY 13:-(2013).
