FGD4
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Official Full Name
FYVE, RhoGEF and PH domain containing 4 -
Overview
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. -
Synonyms
FGD4;FYVE, RhoGEF and PH domain containing 4;FGD1 family, member 4;FYVE, RhoGEF and PH domain-containing protein 4;CMT4H;frabin;FRABP;ZFYVE6;FGD1-related F-actin-binding protein;actin-filament binding protein frabin;zinc finger FYVE domain-conta
Recombinant Proteins
- Rat
- Mouse
- Human
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- Myc&DDK
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FGD4-2322R | Recombinant Rat FGD4 Protein | Mammalian Cell | Rat | His |
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| FGD4-5834M | Recombinant Mouse FGD4 Protein | Mammalian Cell | Mouse | His |
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| FGD4-6253HCL | Recombinant Human FGD4 293 Cell Lysate | HEK293 | Human | Non |
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| FGD4-1979R | Recombinant Rat FGD4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| FGD4-1979R-B | Recombinant Rat FGD4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| FGD4-2306H | Recombinant Human FGD4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| Fgd4-2992M | Recombinant Mouse Fgd4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| FGD4-3222M | Recombinant Mouse FGD4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FGD4-3222M-B | Recombinant Mouse FGD4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| FGD4-4092H | Recombinant Human FGD4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| FGD4-4805HF | Recombinant Full Length Human FGD4 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 766 amino acids |
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Involved Pathway
FGD4 involved in several pathways and played different roles in them. We selected most pathways FGD4 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell death signalling via NRAGE, NRIF and NADE | ARHGEF17,AATF,FGD2,ARHGEF3,ITSN1,ARHGAP4,ARHGEF18,KALRN,ARHGAP4A,ABR |
| Signaling by Rho GTPases | NOXO1A,FAM13B1,IQGAP3,ARHGAP12,FAM13B,MKL1B,ARHGAP17A,ARHGAP22,RHPN2,RHOF |
| Signal Transduction | FMNL1,UCHL5,APOA4A,CRABP1A,TJP2B,ARHGEF1B,GPR55,CHN2,WIF1,RBCK1 |
| NRAGE signals death through JNK | ARHGEF18A,ARHGEF16,DCLRE1B,OBSCN,NET1,ARHGEF3,ECT2,ARHGAP4A,TIAM2,ARHGEF18 |
| Signaling by GPCR | OR10A5,RCA2.1,TAC3,GPR65,UTS2,OPN1LW2,EDNRAB,RGS4,OR52B4,RGS11 |
| GPCR downstream signaling | ARHGEF17,CCR1,GRP,PYY,TRPC6A,LPAR2B,ITSN1,GPR18,CASR,RGS6 |
| Rho GTPase cycle | ARAP1,TAGAP,STARD13,ARHGAP26,DLC1,RHOF,ARHGAP10,GDI1,ARHGAP6,ARHGAP15 |
| G alpha (12/13) signalling events | AKAP13,NET1,OBSCN,RHOC,ARHGEF18,ARHGEF1A,ITSN1,PLEKHG2,FGD2,ECT2 |
Protein Function
FGD4 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,actin binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGD4 itself. We selected most functions FGD4 had, and list some proteins which have the same functions with FGD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | MICAL2B,EMD,TMOD3,LIMCH1,FSCN2B,PFN2L,WASF2,PHACTR1,CNN1A,LIMCH1A |
| small GTPase binding | TSC2,FGD3,GDI2,ABCA1,FGD1,PEX5L,FGD6,RNF152,RCC2,ERRFI1 |
| Rho guanyl-nucleotide exchange factor activity | ARHGEF10L,ITSN2B,FARP1,TRIO,TIAM2,ARHGEF17,ARHGEF1A,FGD1,C3A.1,C9orf100 |
| guanyl-nucleotide exchange factor activity | VAV3B,RASGRP3,DIS3,TAGAP,ARHGEF18,ARHGEF1B,KALRN,ARFGEF2,CHRM4,RANGRF |
| metal ion binding | ESRRGB,HBAE3,ATP13A4,EIF2S2,ATP2B3A,CA15B,CRYAB,WBP4,CALUB,AMHR2 |
Interacting Protein
FGD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGD4.
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References
- Noseda, R; Belin, S; et al. DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination. JOURNAL OF NEUROSCIENCE 33:15295-15305(2013).
- Arai, H; Hayashi, M; et al. The first Japanese case of Charcot Marie Tooth disease type 4H with a novel FGD4 c.837-1G > A mutation. NEUROMUSCULAR DISORDERS 23:652-655(2013).
