FGD1
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Official Full Name
FYVE, RhoGEF and PH domain containing 1 -
Overview
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16. -
Synonyms
FGD1;FYVE, RhoGEF and PH domain containing 1;faciogenital dysplasia (Aarskog Scott syndrome) , FGDY;FYVE, RhoGEF and PH domain-containing protein 1;ZFYVE3;rho/Rac GEF;faciogenital dysplasia 1 protein;zinc finger FYVE domain-containing protein 3;rh
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FGD1-12857H | Recombinant Human FGD1, GST-tagged | E.coli | Human | GST | C-term-351a.a. | |
| FGD1-5831M | Recombinant Mouse FGD1 Protein | Mammalian Cell | Mouse | His |
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| FGD1-1969H | Recombinant Human FGD1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| Fgd1-2990M | Recombinant Mouse Fgd1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| FGD1-3220M | Recombinant Mouse FGD1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| FGD1-3220M-B | Recombinant Mouse FGD1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
FGD1 involved in several pathways and played different roles in them. We selected most pathways FGD1 participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | PFN4,RASSF7,ITGB1,PAK6,SSH2,RHOAB,FGF18A,FGF12A,APC2,GSNB |
Protein Function
FGD1 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,guanyl-nucleotide exchange factor activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGD1 itself. We selected most functions FGD1 had, and list some proteins which have the same functions with FGD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| small GTPase binding | PEX5L,RCC2,PEX5,FGD5,FLNA,ABCA1,GDI2,FGD2,FGD4,ERRFI1 |
| guanyl-nucleotide exchange factor activity | ARHGEF37,RAPGEFL1,TRIOA,ARHGEF7A,ITSN2A,TBXA2R,FNIP1,RASGRP1,SH2D3CB,FLCN |
| Rho guanyl-nucleotide exchange factor activity | PLEKHG5,FGD3,VAV2,ARHGEF11,ARHGEF1,ARHGEF25,ARHGEF3L,VAV3,ARHGEF10,ARHGEF40 |
| metal ion binding | ZFP609,GNAT2,TRIM55A,NR5A5,ZBTB10,FGD,TIMP3,PRKRIR,MAT1A,ZFP770 |
Interacting Protein
FGD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGD1.
b7z9c6_human;ESYT2;PITPNM1;GGCX;TAP2;STX3;FBXL19;MICALL2;MRPL18;INTS7
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References
- Orrico, A; Galli, L; et al. Clinical utility gene card for: Aarskog-Scott Syndrome (faciogenital dysplasia) - update 2015. EUROPEAN JOURNAL OF HUMAN GENETICS 23:-(2015).
- De Wolf, V; Crepel, A; et al. A Complex Xp11.22 Deletion in a Patient With Syndromic Autism: Exploration of FAM120C as a Positional Candidate Gene for Autism. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:3035-3041(2014).
