FER

  • Official Full Name

    fer (fps/fes related) tyrosine kinase

  • Overview

    FER tyrosine kinase is involved in cadherin, PECAM-1, and integrin mediated cytoskeletal connections. More recent research has also linked FER to decreasing the innate immune response. FER has also been implicated in the control of lipopolysaccharide induced epithelial dysfunction. FER has been shown to be essential in microtubule characteristics in the oocyte meiotic spindle and could also play a role in germinal vesicle breakdown.

  • Synonyms

    FER;fer (fps/fes related) tyrosine kinase;tyrosine-protein kinase Fer;phosphoprotein NCP94;PPP1R74;protein phosphatase 1;regulatory subunit 74;TYK3;p94-Fer;tyrosine kinase 3;proto-oncogene c-Fer;feline encephalitis virus-related kinase FER;protein phosphatase 1, regulatory subunit 74;fujinami poultry sarcoma/Feline sarcoma-related protein Fer;FerT

Recombinant Proteins

  • Human
  • Bacillus subtilis
  • E.coli
  • Insect Cell
  • Sf9 Insect Cell
  • E. coli or Yeast
  • Insect (sf21)
  • His
  • GST
  • Non
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
FER-12842H Recombinant Human FER, His-tagged E.coli Human His 96-445a.a.
FER-1869H Recombinant Human FER protein, GST-tagged E.coli Human GST 96-445 aa
FER-2611H Recombinant Human FER, GST-tagged Insect Cell Human GST
FER-2706H Recombinant Human FER, GST-His Sf9 Insect Cell Human GST 541-822 a.a.
FER-1242H Recombinant Human FER protein(563-816aa), His-tagged E.coli Human His 563-816aa
FER-1323S Recombinant Human FER Protein (M1-T822), Tag Free Insect Cell Human Non M1-T822
FER-1324S Recombinant Human FER Protein (M1-T822), GST tagged Insect Cell Human GST M1-T822
FER-2084B Recombinant Bacillus subtilis FER protein, His-tagged E. coli or Yeast Bacillus subtilis His
FER-4073H Active Recombinant Human FER Protein, GST/His-tagged Insect Cell Human His&GST 541-822 a.a.
FER-9911HF Active Recombinant Full Length Human FER Protein, GST-tagged Insect (sf21) Human GST Full L. 1-822(end)

    Involved Pathway

    FER involved in several pathways and played different roles in them. We selected most pathways FER participated on our site, such as Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with FER were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adherens junction TGFBR2,PTPRM,WASLA,RAC1B,MAPK1,TJP1,Fert2,RHOAA,CDC42L2,PVRL1

    Protein Function

    FER has several biochemical functions, for example, ATP binding,Rab GTPase binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FER itself. We selected most functions FER had, and list some proteins which have the same functions with FER. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine kinase activity MAP2K6,INSR,DSTYK,SRMS,CLK3,NEK1,FGFR1OP,SHC1,MATK,KIT
    lipid binding STARD13,FABP1B.1,APODB,BPIFB6,FABP6,LIPF,IQSEC1,PPARA,BPIFB2,ESYT3
    gamma-catenin binding PTPRJ,LEF1,Fert2,DSG1,APC2,TCF7L2,APC,PTPRK,CDH2,DSG1A
    protein kinase binding VRK2,PTPN6,TCF7L2,Fert2,CDK5R1,ARHGEF7,EEF2,NBEA,TICAM1,CCNB1
    protein phosphatase 1 binding Fert2,STAU1,PHACTR4,PHACTR3A,LILRB1,PPP1R9B,PHACTR1,KCNQ1,PHACTR3,PAWR
    Rab GTPase binding ANKRD27,RAB11FIP5,RABGGTA,ULK1,RAB3GAP1,SYTL4,RABGEF1,CCDC64,RABGAP1L,MYRIP
    non-membrane spanning protein tyrosine kinase activity PTK2AB,ABL1,PTK2,FYNB,STYK1,YRK,PRKCD,JAK1,EIF2AK2,TNK2
    actin binding STK38L,FSCN1A,ARPC5L,WAS,WASF3,SSH2,DAAM1,PARVA,CNN1,AKAP5
    epidermal growth factor receptor binding EPGN,RNF126,SOCS5,BTC,LINGO1,SNX2,AREG,YES1,ATXN2,PLSCR1

    Interacting Protein

    FER has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FER here. Most of them are supplied by our site. Hope this information will be useful for your research of FER.

    bosutinib;CDC37;KCTD4;saicar;PTPN1;chBcat;ERBB2;PKM;ERBB3;NSF;Ctnnb1;ABI1;HSP90AB1;PIK3R1;CRK;PPP1R7

    Resources

    References

    • Wanderley, CWS; Silva, CMS; et al. Bothrops jararacussu snake venom-induces a local inflammatory response in a prostanoid- and neutrophil-dependent manner. TOXICON 90:134-147(2014).
    • Redpath, GMI; Woolger, N; et al. Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair. MOLECULAR BIOLOGY OF THE CELL 25:3037-3048(2014).

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