FECH
-
Official Full Name
ferrochelatase -
Overview
The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous;form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with;erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A;pseudogene of this gene is found on chromosome 3. -
Synonyms
FECH;ferrochelatase;ferrochelatase (protoporphyria);ferrochelatase, mitochondrial;protoporphyria;EPP;FCE;Ferrochelatase mitochondrial;Heme synthetase;Protoheme ferro lyase;heme synthase;protoheme ferro-lyase
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Bovine
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- Flag
- His&Myc&SUMO
- GST
- N-His&C-Myc
- His&Fc&Avi
Involved Pathway
FECH involved in several pathways and played different roles in them. We selected most pathways FECH participated on our site, such as Porphyrin and chlorophyll metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FECH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | MSMO1,NME2B.2,FUT4,CYP11B2,AOX2P,CYP11B1,UGT1A4,TK1,PFKM,RPIA |
| Porphyrin and chlorophyll metabolism | P22,ALAS2,UGT1A6,UGT1A7,UGT1A3,UGT1AB,HCCSA.1,UGT2A3,PPOX,BLVRB |
Protein Function
FECH has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,ferrochelatase activity,ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FECH itself. We selected most functions FECH had, and list some proteins which have the same functions with FECH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron-responsive element binding | IREB2,ACO1 |
| 2 iron, 2 sulfur cluster binding | CISD1,CISD2,AIFM4,AOX3,UQCRFS1,FDX1L,FDX1,NDUFV2,AIFM3,GLRX2 |
| protein binding | COIL,ALDH7A1,TMUB2,KCNH7,TADA3,LGR4,SMARCAD1,UROD,COPRS,SMC4 |
| heme binding | CYB5D2,JAK2,CYP2Y3,CYP2C70,CYP2D6,CYP7A1,CYP2P7,IDO2,LPO,CYP2D10 |
| ferrous iron binding | HAAO,ISCUB,Trf,TF,CDO1,ISCA2,BCO1,SNCA,ISCA1,SERPINB1A |
Interacting Protein
FECH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FECH here. Most of them are supplied by our site. Hope this information will be useful for your research of FECH.
Ppp2r1a;USP42;USP20;ATM;gag-pol;MME;Alas2;Fech;PPP2R1A;Cpox;Slc25a4;Ppox;Slc25a5;PPP2CB;PPP2CA;CLPP;Vdac2;Abcb7
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References
- Afshar-Oromieh, A; Avtzi, E; et al. The diagnostic value of PET/CT imaging with the Ga-68-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 42:197-209(2015).
- Barman-Aksozen, J; Minder, EI; et al. In ferrochelatase-deficient protoporphyria patients, ALAS2 expression is enhanced and erythrocytic protoporphyrin concentration correlates with iron availability. BLOOD CELLS MOLECULES AND DISEASES 54:71-77(2015).
